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• W2089165045 endingPage "369" @default.
• W2089165045 startingPage "363" @default.
• W2089165045 abstract "The central enzyme on the de novo pathway for synthesis of DNA precursors, the deoxyribonucleoside triphosphates, is ribonucleotide reductase (RNR). Deoxythymidine triphosphate (dTTP) has a key role in control of RNR activity shifting the specificity from pyrimidine to purine nucleotide reduction. Apart from the complex de novo synthesis of dTTP through UDP reduction, dTTP is provided through salvage of thymidine catalyzed by the thymidine kinases, the cytosolic and cell cycle regulated TK1 and the mitochondrial and constitutively expressed TK2. The complex enzymatic regulation of TK1 and TK2 and the possible physiological significance of this regulation will be discussed." @default.
• W2089165045 created "2016-06-24" @default.
• W2089165045 creator A5016894999 @default.
• W2089165045 date "2010-06-10" @default.
• W2089165045 modified "2023-10-06" @default.
• W2089165045 title "Enzymatic Regulation of Cytosolic Thymidine Kinase 1 and Mitochondrial Thymidine Kinase 2: A Mini Review" @default.
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• W2089165045 doi "https://doi.org/10.1080/15257771003729591" @default.
• W2089165045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20544521" @default.
• W2089165045 hasPublicationYear "2010" @default.
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