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• W2089178339 abstract "The effects of acute or chronic ethanol on serotonin (5-HT)-induced membrane hyperpolarization and inhibition of the slow Ca2+-dependent after hyperpolarization (sAHP) were recorded in rat CA1 pyramidal neurons in hippocampal slices using sharp intracellular electrodes. 5-HT (1–100 μM) caused concentration-dependent hyperpolarization of the membrane that was not altered by simultaneous 30 mM ethanol treatment, but blunted by 10 μM buspirone, a weak 5-HT1A agonist. 5-HT (1–30 μM) also partially inhibited (≈ 40%) the sAHP following a burst of five or more action potentials. Initially ethanol (30 mM) alone did not alter the sAHP, but over a period of 38 min, a slow increase in amplitude (≈ 40%) was observed. 5-HT-mediated inhibition of the sAHP was significantly greater with ethanol present, regardless of the length of exposure. Pyramidal neurons in hippocampal slices prepared from ethanol-dependent animals showed no obvious signs of withdrawal related hyperexcitability and neither concentration-dependent membrane hyperpolarization nor sAHP inhibition caused by 5-HT were significantly changed from responses in controls. These results suggest that hyperpolarizing responses to 5-HT in hippocampal CA1 pyramidal neurons are functionally resistant to acute or chronic ethanol treatment. 5-HT-mediated inhibition of the sAHP is enhanced by ethanol acutely, but does not show an adaptive change as a result of ethanol dependence." @default.
• W2089178339 created "2016-06-24" @default.
• W2089178339 creator A5036470013 @default.
• W2089178339 creator A5063384572 @default.
• W2089178339 date "1996-08-01" @default.
• W2089178339 modified "2023-10-18" @default.
• W2089178339 title "Acute and chronic actions of ethanol on CA1 hippocampal responses to serotonin" @default.
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• W2089178339 doi "https://doi.org/10.1016/0006-8993(96)00459-3" @default.
• W2089178339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8883849" @default.
• W2089178339 hasPublicationYear "1996" @default.
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