FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089182735> ?p ?o ?g. }

• W2089182735 endingPage "4626" @default.
• W2089182735 startingPage "4618" @default.
• W2089182735 abstract "Different subregions of nucleus accumbens (NAc) have been implicated in reward seeking, promoting flexible approach responses, suppressing nonrewarded actions, and facilitating shifts between different discrimination strategies. Interestingly, the NAc does not appear to mediate shifting between stimulus–reward associations (i.e., reversal learning) when reinforcement is predictable. How these nuclei may facilitate flexible response strategies when reward delivery is uncertain remains unclear. We investigated the effects of inactivation of the NAc shell and core on probabilistic reversal learning using an operant task wherein a “correct” response delivered reward on 80% of trials, and an “incorrect” response was reinforced on 20% of trials. Reinforcement contingencies were reversed repeatedly within a session. In well-trained rats, shell inactivation reduced the number of reversals completed and selectively reduced win–stay behavior. This impairment was apparent during the first discrimination, indicating a more general deficit in the use of probabilistic reward feedback to guide action selection. Shell inactivation also impaired reversal performance on a similar task where correct/incorrect choices always/never delivered reward. However, this impairment only emerged after both levers had been associated with reward. Inactivation of NAc core did not impair reversal performance but increased latencies to approach the response levers. These results suggest the NAc shell and core facilitate reward seeking in a distinct yet complementary manner when the relationship between specific actions and reward is uncertain or ambiguous and cognitive flexibility is required. The core promotes approach toward reward-associated stimuli, whereas the shell refines response selection to those specific actions more likely to yield reward." @default.
• W2089182735 created "2016-06-24" @default.
• W2089182735 creator A5034827079 @default.
• W2089182735 creator A5043318987 @default.
• W2089182735 creator A5081137194 @default.
• W2089182735 date "2014-03-26" @default.
• W2089182735 modified "2023-10-10" @default.
• W2089182735 title "Preferential Involvement by Nucleus Accumbens Shell in Mediating Probabilistic Learning and Reversal Shifts" @default.
• W2089182735 cites W1488496267 @default.
• W2089182735 cites W1948130162 @default.
• W2089182735 cites W1964859800 @default.
• W2089182735 cites W1969798355 @default.
• W2089182735 cites W1973466311 @default.
• W2089182735 cites W1977494907 @default.
• W2089182735 cites W1980321165 @default.
• W2089182735 cites W1984003649 @default.
• W2089182735 cites W1988033860 @default.
• W2089182735 cites W1989606433 @default.
• W2089182735 cites W1989637315 @default.
• W2089182735 cites W1992693193 @default.
• W2089182735 cites W1994892862 @default.
• W2089182735 cites W2002272045 @default.
• W2089182735 cites W2006749296 @default.
• W2089182735 cites W2010547854 @default.
• W2089182735 cites W2013952470 @default.
• W2089182735 cites W2017386708 @default.
• W2089182735 cites W2019645577 @default.
• W2089182735 cites W2020902468 @default.
• W2089182735 cites W2024086265 @default.
• W2089182735 cites W2025039841 @default.
• W2089182735 cites W2028291191 @default.
• W2089182735 cites W2029037648 @default.
• W2089182735 cites W2041529027 @default.
• W2089182735 cites W2043729058 @default.
• W2089182735 cites W2051944193 @default.
• W2089182735 cites W2059047773 @default.
• W2089182735 cites W2073158860 @default.
• W2089182735 cites W2075588319 @default.
• W2089182735 cites W2077299896 @default.
• W2089182735 cites W2077529464 @default.
• W2089182735 cites W2080835165 @default.
• W2089182735 cites W2085090249 @default.
• W2089182735 cites W2086218381 @default.
• W2089182735 cites W2087317580 @default.
• W2089182735 cites W2098736996 @default.
• W2089182735 cites W2098906776 @default.
• W2089182735 cites W2104254530 @default.
• W2089182735 cites W2114022439 @default.
• W2089182735 cites W2120424352 @default.
• W2089182735 cites W2131624282 @default.
• W2089182735 cites W2139406973 @default.
• W2089182735 cites W2141556360 @default.
• W2089182735 cites W2148344859 @default.
• W2089182735 cites W2154800141 @default.
• W2089182735 cites W2158052449 @default.
• W2089182735 cites W2162074174 @default.
• W2089182735 cites W2167746245 @default.
• W2089182735 cites W2168122820 @default.
• W2089182735 cites W4235235686 @default.
• W2089182735 cites W4241234786 @default.
• W2089182735 cites W4252486213 @default.
• W2089182735 doi "https://doi.org/10.1523/jneurosci.5058-13.2014" @default.
• W2089182735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6608131" @default.
• W2089182735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24672007" @default.
• W2089182735 hasPublicationYear "2014" @default.
• W2089182735 type Work @default.
• W2089182735 sameAs 2089182735 @default.
• W2089182735 citedByCount "77" @default.
• W2089182735 countsByYear W20891827352014 @default.
• W2089182735 countsByYear W20891827352015 @default.
• W2089182735 countsByYear W20891827352016 @default.
• W2089182735 countsByYear W20891827352017 @default.
• W2089182735 countsByYear W20891827352018 @default.
• W2089182735 countsByYear W20891827352019 @default.
• W2089182735 countsByYear W20891827352020 @default.
• W2089182735 countsByYear W20891827352021 @default.
• W2089182735 countsByYear W20891827352022 @default.
• W2089182735 countsByYear W20891827352023 @default.
• W2089182735 crossrefType "journal-article" @default.
• W2089182735 hasAuthorship W2089182735A5034827079 @default.
• W2089182735 hasAuthorship W2089182735A5043318987 @default.
• W2089182735 hasAuthorship W2089182735A5081137194 @default.
• W2089182735 hasBestOaLocation W20891827351 @default.
• W2089182735 hasConcept C154945302 @default.
• W2089182735 hasConcept C15744967 @default.
• W2089182735 hasConcept C169760540 @default.
• W2089182735 hasConcept C169900460 @default.
• W2089182735 hasConcept C180747234 @default.
• W2089182735 hasConcept C2776552330 @default.
• W2089182735 hasConcept C2779918689 @default.
• W2089182735 hasConcept C41008148 @default.
• W2089182735 hasConcept C49937458 @default.
• W2089182735 hasConcept C513476851 @default.
• W2089182735 hasConcept C66102695 @default.
• W2089182735 hasConcept C67203356 @default.
• W2089182735 hasConcept C77805123 @default.
• W2089182735 hasConcept C97541855 @default.
• W2089182735 hasConceptScore W2089182735C154945302 @default.

• next