FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089183490> ?p ?o ?g. }

• W2089183490 endingPage "3086" @default.
• W2089183490 startingPage "3078" @default.
• W2089183490 abstract "Ethylene cross-bridged tetraamine macrocycles are useful chelators in coordination, catalytic, medicinal, and radiopharmaceutical chemistry. Springborg and co-workers developed trimethylene cross-bridged analogues, although their pendant-armed derivatives received little attention. We report here the synthesis of a bis-carboxymethyl pendant-armed cyclen with a trimethylene cross-bridge (C3B-DO2A) and its isomeric ethylene-cross-bridged homocyclen ligand (CB-TR2A) as well as their copper(II) complexes. The in vitro and in vivo properties of these complexes are compared with respect to their potential application as (64)Cu-radiopharmaceuticals in positron emission tomography (PET imaging). The inertness of Cu-C3B-DO2A to decomplexation is remarkable, exceeding that of Cu-CB-TE2A. Electrochemical reduction of Cu-CB-TR2A is quasi-reversible, whereas that of Cu-C3B-DO2A is irreversible. The reaction conditions for preparing (64)Cu-C3B-DO2A (microwaving at high temperature) are relatively harsh compared to (64)Cu-CB-TR2A (basic ethanol). The in vivo behavior of the (64)Cu complexes was evaluated in normal rats. Rapid and continual clearance of (64)Cu-CB-TR2A through the blood, liver, and kidneys suggests relatively good in vivo stability, albeit inferior to (64)Cu-CB-TE2A. Although (64)Cu-C3B-DO2A clears continually, the initial uptake is high and only about half is excreted within 22 h, suggesting poor stability and transchelation of (64)Cu to proteins in the blood and/or liver. These data suggest that in vitro inertness of a chelator complex may not always be a good indicator of in vivo stability." @default.
• W2089183490 created "2016-06-24" @default.
• W2089183490 creator A5002367405 @default.
• W2089183490 creator A5006499895 @default.
• W2089183490 creator A5012205679 @default.
• W2089183490 creator A5029437028 @default.
• W2089183490 creator A5038489432 @default.
• W2089183490 creator A5041158475 @default.
• W2089183490 creator A5042426879 @default.
• W2089183490 creator A5048743855 @default.
• W2089183490 creator A5052383660 @default.
• W2089183490 creator A5057803757 @default.
• W2089183490 creator A5058148292 @default.
• W2089183490 creator A5066706584 @default.
• W2089183490 date "2011-04-04" @default.
• W2089183490 modified "2023-10-10" @default.
• W2089183490 title "Isomeric Trimethylene and Ethylene Pendant-armed Cross-bridged Tetraazamacrocycles and in Vitro/in Vivo Comparisions of their Copper(II) Complexes" @default.
• W2089183490 doi "https://doi.org/10.1021/ic200014w" @default.
• W2089183490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3065210" @default.
• W2089183490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21381676" @default.
• W2089183490 hasPublicationYear "2011" @default.
• W2089183490 type Work @default.
• W2089183490 sameAs 2089183490 @default.
• W2089183490 citedByCount "29" @default.
• W2089183490 countsByYear W20891834902012 @default.
• W2089183490 countsByYear W20891834902013 @default.
• W2089183490 countsByYear W20891834902014 @default.
• W2089183490 countsByYear W20891834902015 @default.
• W2089183490 countsByYear W20891834902016 @default.
• W2089183490 countsByYear W20891834902017 @default.
• W2089183490 countsByYear W20891834902019 @default.
• W2089183490 countsByYear W20891834902020 @default.
• W2089183490 countsByYear W20891834902022 @default.
• W2089183490 countsByYear W20891834902023 @default.
• W2089183490 crossrefType "journal-article" @default.
• W2089183490 hasAuthorship W2089183490A5002367405 @default.
• W2089183490 hasAuthorship W2089183490A5006499895 @default.
• W2089183490 hasAuthorship W2089183490A5012205679 @default.
• W2089183490 hasAuthorship W2089183490A5029437028 @default.
• W2089183490 hasAuthorship W2089183490A5038489432 @default.
• W2089183490 hasAuthorship W2089183490A5041158475 @default.
• W2089183490 hasAuthorship W2089183490A5042426879 @default.
• W2089183490 hasAuthorship W2089183490A5048743855 @default.
• W2089183490 hasAuthorship W2089183490A5052383660 @default.
• W2089183490 hasAuthorship W2089183490A5057803757 @default.
• W2089183490 hasAuthorship W2089183490A5058148292 @default.
• W2089183490 hasAuthorship W2089183490A5066706584 @default.
• W2089183490 hasBestOaLocation W20891834901 @default.
• W2089183490 hasConcept C116569031 @default.
• W2089183490 hasConcept C13965031 @default.
• W2089183490 hasConcept C150903083 @default.
• W2089183490 hasConcept C155647269 @default.
• W2089183490 hasConcept C161790260 @default.
• W2089183490 hasConcept C170493617 @default.
• W2089183490 hasConcept C178790620 @default.
• W2089183490 hasConcept C179104552 @default.
• W2089183490 hasConcept C185592680 @default.
• W2089183490 hasConcept C188027245 @default.
• W2089183490 hasConcept C197404232 @default.
• W2089183490 hasConcept C202751555 @default.
• W2089183490 hasConcept C207001950 @default.
• W2089183490 hasConcept C2777459166 @default.
• W2089183490 hasConcept C2778597550 @default.
• W2089183490 hasConcept C544778455 @default.
• W2089183490 hasConcept C55493867 @default.
• W2089183490 hasConcept C71240020 @default.
• W2089183490 hasConcept C86803240 @default.
• W2089183490 hasConceptScore W2089183490C116569031 @default.
• W2089183490 hasConceptScore W2089183490C13965031 @default.
• W2089183490 hasConceptScore W2089183490C150903083 @default.
• W2089183490 hasConceptScore W2089183490C155647269 @default.
• W2089183490 hasConceptScore W2089183490C161790260 @default.
• W2089183490 hasConceptScore W2089183490C170493617 @default.
• W2089183490 hasConceptScore W2089183490C178790620 @default.
• W2089183490 hasConceptScore W2089183490C179104552 @default.
• W2089183490 hasConceptScore W2089183490C185592680 @default.
• W2089183490 hasConceptScore W2089183490C188027245 @default.
• W2089183490 hasConceptScore W2089183490C197404232 @default.
• W2089183490 hasConceptScore W2089183490C202751555 @default.
• W2089183490 hasConceptScore W2089183490C207001950 @default.
• W2089183490 hasConceptScore W2089183490C2777459166 @default.
• W2089183490 hasConceptScore W2089183490C2778597550 @default.
• W2089183490 hasConceptScore W2089183490C544778455 @default.
• W2089183490 hasConceptScore W2089183490C55493867 @default.
• W2089183490 hasConceptScore W2089183490C71240020 @default.
• W2089183490 hasConceptScore W2089183490C86803240 @default.
• W2089183490 hasFunder F4320332161 @default.
• W2089183490 hasIssue "7" @default.
• W2089183490 hasLocation W20891834901 @default.
• W2089183490 hasLocation W20891834902 @default.
• W2089183490 hasLocation W20891834903 @default.
• W2089183490 hasLocation W20891834904 @default.
• W2089183490 hasOpenAccess W2089183490 @default.
• W2089183490 hasPrimaryLocation W20891834901 @default.
• W2089183490 hasRelatedWork W1967289096 @default.
• W2089183490 hasRelatedWork W1970341253 @default.
• W2089183490 hasRelatedWork W2020325842 @default.
• W2089183490 hasRelatedWork W2054815863 @default.

• next