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- W2089185106 abstract "Treatment of mice for 12 weeks with clofazimine or kanamycin decreased the number of organisms from lungs, liver and spleen of mice infected with Mycobacterium intracellulare N-260, compared with findings seen with rifabutin or ethambutol. Treatment with various drug combinations (rifabutin-ethambutol, rifabutin-clofazimine, rifabutin-kanamycin, rifabutin-ethambutol-clofazimine, rifabutin-ethambutol-kanamycin, and rifabutin-clofazimine-kanamycin), particularly in the presence of clofazimine, enhanced elimination of the organisms from these organs. Le traitement pendant 12 semaines par la clofazimine ou la kanamycine diminue le nombre de microorganismes au niveau des poumons, du foie et de la rate des souris infectées par Mycobacterium intracellulare N-260, si l'on compare le résultat avec ces médicaments à ceux obtenus avec la rifabutine ou l'éthambutol. Le traitement avec diverses associations de médicaments (rifabutine-éthambutol, rifabutine-clofazamine, rifabutine-kanamycine, rifabutine-ethambutol, clofazimine, rifabutine-ethambutol-kanamycine et rifabutine-clofazimine-kanamycine), en particulier en présence de clofazimine, augmente l'élimination des microorganismes de ces organes. Un tratamiento de 12 semanas con clofazimina o kanamicina disminuye el número de microorganismos a nivel de pulmones, hígado y bazo de rratas infectadas con Mycobacterium intracellulare N-260, si se comparan los resultados a los obtenidos con rifabutina o etambutol. El tratamiento con diversas asociaciones de medicamentos (rifabutina-etambutol, rifabutina-clofizimina, rifabutina-kanamicina, rifabutina-etambutol-clofazimina, rifabutina-etambutol-kanamicina, rifabutina-clofazimina-kanamicina), en particular en presencia de clofazimina aumenta la eliminación de microorganismos de estos órganos." @default.
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- W2089185106 date "1989-09-01" @default.
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- W2089185106 title "Activity of rifabutin alone and in combination with clofammine, kanamycin and ethambutol against Mycobacterium intracellulare infections in mice" @default.
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- W2089185106 doi "https://doi.org/10.1016/0041-3879(89)90051-2" @default.
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