FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089190886> ?p ?o ?g. }

• W2089190886 endingPage "37" @default.
• W2089190886 startingPage "37" @default.
• W2089190886 abstract "The last influenza A pandemic provided an excellent opportunity to study the adaptation of the influenza A(H1N1)pdm09 virus to the human host. Particularly, due to the availability of sequences taken from isolates since the beginning of the pandemic until date, we could monitor amino acid changes that occurred in the hemagglutinin (HA) as the virus spread worldwide and became the dominant H1N1 strain. HA is crucial to viral infection because it binds to sialidated cell-receptors and mediates fusion of cell and viral membranes; because antibodies that bind to HA may block virus entry to the cell, this protein is subjected to high selective pressure. Multiple alignment analysis of sequences of the HA from isolates taken since 2009 to date allowed us to find amino acid changes that were positively selected as the pandemic progressed. We found nine changes that became prevalent: HA1 subunits D104N, K166Q, S188T, S206T, A259T, and K285E; and HA2 subunits E47K, S124N, and E172K. Most of these changes were located in areas involved in inter- and intrachain interactions, while only two (K166Q and S188T) were located in known antigenic sites. We conclude that selective pressure on HA was aimed to improve its functionality and hence virus fitness, rather than at avoidance of immune recognition." @default.
• W2089190886 created "2016-06-24" @default.
• W2089190886 creator A5024903290 @default.
• W2089190886 creator A5047905566 @default.
• W2089190886 creator A5051987098 @default.
• W2089190886 creator A5086459849 @default.
• W2089190886 date "2014-10-01" @default.
• W2089190886 modified "2023-09-23" @default.
• W2089190886 title "The hemagglutinin of the influenza A(H1N1)pdm09 is mutating towards stability" @default.
• W2089190886 cites W1483247593 @default.
• W2089190886 cites W1976328520 @default.
• W2089190886 cites W2014346706 @default.
• W2089190886 cites W2015030454 @default.
• W2089190886 cites W2016677998 @default.
• W2089190886 cites W2039967026 @default.
• W2089190886 cites W2041753380 @default.
• W2089190886 cites W2045804017 @default.
• W2089190886 cites W2049788122 @default.
• W2089190886 cites W2051781399 @default.
• W2089190886 cites W2092342138 @default.
• W2089190886 cites W2096091144 @default.
• W2089190886 cites W2104589227 @default.
• W2089190886 cites W2116845530 @default.
• W2089190886 cites W2118794822 @default.
• W2089190886 cites W2119362018 @default.
• W2089190886 cites W2120819598 @default.
• W2089190886 cites W2121009566 @default.
• W2089190886 cites W2124171593 @default.
• W2089190886 cites W2130290436 @default.
• W2089190886 cites W2150768033 @default.
• W2089190886 cites W2151776346 @default.
• W2089190886 cites W2151803596 @default.
• W2089190886 cites W2160107780 @default.
• W2089190886 cites W2169979510 @default.
• W2089190886 doi "https://doi.org/10.2147/aabc.s68934" @default.
• W2089190886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4198066" @default.
• W2089190886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25328411" @default.
• W2089190886 hasPublicationYear "2014" @default.
• W2089190886 type Work @default.
• W2089190886 sameAs 2089190886 @default.
• W2089190886 citedByCount "15" @default.
• W2089190886 countsByYear W20891908862016 @default.
• W2089190886 countsByYear W20891908862017 @default.
• W2089190886 countsByYear W20891908862018 @default.
• W2089190886 countsByYear W20891908862019 @default.
• W2089190886 countsByYear W20891908862020 @default.
• W2089190886 countsByYear W20891908862021 @default.
• W2089190886 countsByYear W20891908862022 @default.
• W2089190886 countsByYear W20891908862023 @default.
• W2089190886 crossrefType "journal-article" @default.
• W2089190886 hasAuthorship W2089190886A5024903290 @default.
• W2089190886 hasAuthorship W2089190886A5047905566 @default.
• W2089190886 hasAuthorship W2089190886A5051987098 @default.
• W2089190886 hasAuthorship W2089190886A5086459849 @default.
• W2089190886 hasBestOaLocation W20891908861 @default.
• W2089190886 hasConcept C105702510 @default.
• W2089190886 hasConcept C142724271 @default.
• W2089190886 hasConcept C159047783 @default.
• W2089190886 hasConcept C159654299 @default.
• W2089190886 hasConcept C2522874641 @default.
• W2089190886 hasConcept C2777546802 @default.
• W2089190886 hasConcept C2778022156 @default.
• W2089190886 hasConcept C2778692840 @default.
• W2089190886 hasConcept C2779134260 @default.
• W2089190886 hasConcept C3008058167 @default.
• W2089190886 hasConcept C515207424 @default.
• W2089190886 hasConcept C524204448 @default.
• W2089190886 hasConcept C54355233 @default.
• W2089190886 hasConcept C71924100 @default.
• W2089190886 hasConcept C7842527 @default.
• W2089190886 hasConcept C82988372 @default.
• W2089190886 hasConcept C86803240 @default.
• W2089190886 hasConcept C89623803 @default.
• W2089190886 hasConceptScore W2089190886C105702510 @default.
• W2089190886 hasConceptScore W2089190886C142724271 @default.
• W2089190886 hasConceptScore W2089190886C159047783 @default.
• W2089190886 hasConceptScore W2089190886C159654299 @default.
• W2089190886 hasConceptScore W2089190886C2522874641 @default.
• W2089190886 hasConceptScore W2089190886C2777546802 @default.
• W2089190886 hasConceptScore W2089190886C2778022156 @default.
• W2089190886 hasConceptScore W2089190886C2778692840 @default.
• W2089190886 hasConceptScore W2089190886C2779134260 @default.
• W2089190886 hasConceptScore W2089190886C3008058167 @default.
• W2089190886 hasConceptScore W2089190886C515207424 @default.
• W2089190886 hasConceptScore W2089190886C524204448 @default.
• W2089190886 hasConceptScore W2089190886C54355233 @default.
• W2089190886 hasConceptScore W2089190886C71924100 @default.
• W2089190886 hasConceptScore W2089190886C7842527 @default.
• W2089190886 hasConceptScore W2089190886C82988372 @default.
• W2089190886 hasConceptScore W2089190886C86803240 @default.
• W2089190886 hasConceptScore W2089190886C89623803 @default.
• W2089190886 hasLocation W20891908861 @default.
• W2089190886 hasLocation W20891908862 @default.
• W2089190886 hasLocation W20891908863 @default.
• W2089190886 hasLocation W20891908864 @default.
• W2089190886 hasOpenAccess W2089190886 @default.
• W2089190886 hasPrimaryLocation W20891908861 @default.
• W2089190886 hasRelatedWork W2057700014 @default.

• next