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• W2089199245 abstract "Abstract Melanoma antigen recognized by T cell 1 (MART‐1) is regarded as a candidate peptide for vaccination against malignant melanoma, and it is of importance to develop strategies to improve the vaccine‐elicited T‐cell activation towards MART‐1. T‐cell activation is, among other determinants, dependent on the density of specific major histocompatibility complex–peptide complexes on the surface of the antigen‐presenting cell. In this study, we explored the cell‐surface presentation of a substituted MART‐1 peptide encoded by transfected minigenes. We investigated the potential of proteasomal targeting compared to non‐proteasomal targeting of the epitope to increase its cell‐surface presentation. Furthermore, we explored the potential of incorporating multiple minigenes instead of one to increase cell‐surface presentation. We show that both proteasomal targeting and repetition of the minigene increase cell‐surface presentation of the epitope and propose both these approaches as potential strategies in DNA vaccines to increase MART‐1‐specific T‐cell activation." @default.
• W2089199245 created "2016-06-24" @default.
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• W2089199245 date "2004-02-01" @default.
• W2089199245 modified "2023-10-10" @default.
• W2089199245 title "Proteasomal Targeting and Minigene Repetition Improve Cell-Surface Presentation of a Transfected, Modified Melanoma Tumour Antigen" @default.
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• W2089199245 doi "https://doi.org/10.1111/j.0300-9475.2004.01374.x" @default.
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