Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089205087> ?p ?o ?g. }
- W2089205087 endingPage "5568" @default.
- W2089205087 startingPage "5554" @default.
- W2089205087 abstract "ERAL1, a homologue of Era protein in Escherichia coli, is a member of conserved GTP-binding proteins with RNA-binding activity. Depletion of prokaryotic Era inhibits cell division without affecting chromosome segregation. Previously, we isolated ERAL1 protein as one of proteins which were associated with mitochondrial transcription factor A by using immunoprecipitation. In this study, we analysed the localization and function of ERAL1 in mammalian cells. ERAL1 was localized in mitochondrial matrix and associated with mitoribosomal proteins including the 12S rRNA. siRNA knockdown of ERAL1 decreased mitochondrial translation, caused redistribution of ribosomal small subunits and reduced 12S rRNA. The knockdown of ERAL1 in human HeLa cells elevated mitochondrial superoxide production and slightly decreased mitochondrial membrane potential. The knockdown inhibited the growth of HeLa cells with an accumulation of apoptotic cells. These results suggest that ERAL1 is localized in a small subunit of the mitochondrial ribosome, plays an important role in the small ribosomal constitution, and is also involved in cell viability." @default.
- W2089205087 created "2016-06-24" @default.
- W2089205087 creator A5007606729 @default.
- W2089205087 creator A5010982285 @default.
- W2089205087 creator A5048450089 @default.
- W2089205087 creator A5056794320 @default.
- W2089205087 creator A5059010005 @default.
- W2089205087 creator A5072555955 @default.
- W2089205087 creator A5079543730 @default.
- W2089205087 date "2010-04-29" @default.
- W2089205087 modified "2023-10-13" @default.
- W2089205087 title "ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation" @default.
- W2089205087 cites W1774344187 @default.
- W2089205087 cites W1871148721 @default.
- W2089205087 cites W1972495784 @default.
- W2089205087 cites W1975529948 @default.
- W2089205087 cites W1986162480 @default.
- W2089205087 cites W1994093290 @default.
- W2089205087 cites W1996592585 @default.
- W2089205087 cites W1997637247 @default.
- W2089205087 cites W2003604497 @default.
- W2089205087 cites W2012523104 @default.
- W2089205087 cites W2017284374 @default.
- W2089205087 cites W2017858225 @default.
- W2089205087 cites W2025779835 @default.
- W2089205087 cites W2027392280 @default.
- W2089205087 cites W2037134079 @default.
- W2089205087 cites W2045778300 @default.
- W2089205087 cites W2049193338 @default.
- W2089205087 cites W2050729907 @default.
- W2089205087 cites W2055302859 @default.
- W2089205087 cites W2061594903 @default.
- W2089205087 cites W2062753466 @default.
- W2089205087 cites W2063639400 @default.
- W2089205087 cites W2067322059 @default.
- W2089205087 cites W2069240622 @default.
- W2089205087 cites W2069473693 @default.
- W2089205087 cites W2073706859 @default.
- W2089205087 cites W2074222405 @default.
- W2089205087 cites W2082531876 @default.
- W2089205087 cites W2084228837 @default.
- W2089205087 cites W2087434357 @default.
- W2089205087 cites W2092416880 @default.
- W2089205087 cites W2095959555 @default.
- W2089205087 cites W2096974898 @default.
- W2089205087 cites W2101745552 @default.
- W2089205087 cites W2119165025 @default.
- W2089205087 cites W2123502134 @default.
- W2089205087 cites W2126215071 @default.
- W2089205087 cites W2126409180 @default.
- W2089205087 cites W2131293378 @default.
- W2089205087 cites W2141228891 @default.
- W2089205087 cites W2149490130 @default.
- W2089205087 cites W2154802086 @default.
- W2089205087 cites W2158728023 @default.
- W2089205087 cites W2165552051 @default.
- W2089205087 cites W2170076251 @default.
- W2089205087 cites W2172052297 @default.
- W2089205087 doi "https://doi.org/10.1093/nar/gkq305" @default.
- W2089205087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2938226" @default.
- W2089205087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20430825" @default.
- W2089205087 hasPublicationYear "2010" @default.
- W2089205087 type Work @default.
- W2089205087 sameAs 2089205087 @default.
- W2089205087 citedByCount "83" @default.
- W2089205087 countsByYear W20892050872012 @default.
- W2089205087 countsByYear W20892050872013 @default.
- W2089205087 countsByYear W20892050872014 @default.
- W2089205087 countsByYear W20892050872015 @default.
- W2089205087 countsByYear W20892050872016 @default.
- W2089205087 countsByYear W20892050872017 @default.
- W2089205087 countsByYear W20892050872018 @default.
- W2089205087 countsByYear W20892050872019 @default.
- W2089205087 countsByYear W20892050872020 @default.
- W2089205087 countsByYear W20892050872021 @default.
- W2089205087 countsByYear W20892050872022 @default.
- W2089205087 countsByYear W20892050872023 @default.
- W2089205087 crossrefType "journal-article" @default.
- W2089205087 hasAuthorship W2089205087A5007606729 @default.
- W2089205087 hasAuthorship W2089205087A5010982285 @default.
- W2089205087 hasAuthorship W2089205087A5048450089 @default.
- W2089205087 hasAuthorship W2089205087A5056794320 @default.
- W2089205087 hasAuthorship W2089205087A5059010005 @default.
- W2089205087 hasAuthorship W2089205087A5072555955 @default.
- W2089205087 hasAuthorship W2089205087A5079543730 @default.
- W2089205087 hasBestOaLocation W20892050871 @default.
- W2089205087 hasConcept C104317684 @default.
- W2089205087 hasConcept C153911025 @default.
- W2089205087 hasConcept C173396325 @default.
- W2089205087 hasConcept C2780090675 @default.
- W2089205087 hasConcept C28859421 @default.
- W2089205087 hasConcept C38062823 @default.
- W2089205087 hasConcept C55493867 @default.
- W2089205087 hasConcept C67705224 @default.
- W2089205087 hasConcept C67905577 @default.
- W2089205087 hasConcept C86803240 @default.
- W2089205087 hasConcept C88478588 @default.
- W2089205087 hasConcept C95444343 @default.