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• W2089214919 abstract "Objective The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility. Methods We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. Results A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21–1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48–4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42–2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24–1.83, P<0.0001), adults and children (OR = 1.43, 95 CI% = 1.07–1.91, P = 0.02; OR = 1.57, 95% CI = 1.19–2.06, P = 0.001). Conclusions This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma." @default.
• W2089214919 created "2016-06-24" @default.
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• W2089214919 date "2014-06-17" @default.
• W2089214919 modified "2023-09-26" @default.
• W2089214919 title "Association between Tumor Necrosis Factor-α rs1800629 Polymorphism and Risk of Asthma: A Meta-Analysis" @default.
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• W2089214919 doi "https://doi.org/10.1371/journal.pone.0099962" @default.
• W2089214919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4061054" @default.
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