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- W2089217245 abstract "In 2008 Wright et al. proposed a mixture model (WMM) in which fetal NT follows two distributions, CRL-dependent and CRL-independent. The proportion of these two components slightly increases with CRL. However, this model supposes a constant CRL-independent variability in both distributions. As in fetal biometry most biometrical parameters show an increasing variability with gestational age, the aim of this study was to establish a mixture model using different method allowing the change of variability. This was retrospective study of singleton pregnancies (CRL 45-81 mm) which underwent routine first-trimester screening in Centre of Fetal Medicine Gennet in Prague from January 2005 till March 2014. The pregnancies with any chromosomal anomaly were excluded. Our assumption was that NT measurements on logarithmic scale follow a mixture of two normal distributions, N(μ, σ2) and N(τ, ν2), with p and (1-p) probabilities that each value comes from first and second distributions, respectively. Our dataset was divided into 9 groups with 4mm CRL increments. For each group the parameters p, μ, σ, τ and ν were estimated with 95% CI using maximum likelihood estimation. The obtained model was compared to WMM. There were 28716 NT measurements eligible for the study. The proportion of CRL-dependent NT was slightly higher than in WMM and increased with CRL from 0.93 to 0.98. Regarding CRL-dependent NT distribution, median NT increased with CRL significantly lower compared to WMM. Looking at CRL-independent NT distribution, median NT slightly increased up to CRL of 67mm, then dropped backwards to the level exactly same as in WMM. The variabilities in both distributions did not show any distinct trend and was similar to WMM. Our established mixture model of NT distribution showed overall concordance with previously published model. The main differences were slightly higher proportion of CRL-dependent component and more gradual increase of NT median in CRL-dependent NT. The variability in both distributions did not show any clear trend with CRL." @default.
- W2089217245 created "2016-06-24" @default.
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- W2089217245 date "2014-09-01" @default.
- W2089217245 modified "2023-10-02" @default.
- W2089217245 title "P01.11: The distribution of nuchal translucency in unaffected pregnancies: a mixture model revisited" @default.
- W2089217245 doi "https://doi.org/10.1002/uog.13997" @default.
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