FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089260826> ?p ?o ?g. }

• W2089260826 endingPage "197" @default.
• W2089260826 startingPage "191" @default.
• W2089260826 abstract "Objective: Inflammatory cytokines may influence both labile anger and depression. Both psychiatric conditions can occur during interferon alfa-based treatments. Evidence also indicates a central nervous system role for tumor necrosis factor α (TNF-α), whose expression may be increased by interferon alfa. A polymorphism in the promoter region of TNF-α has been associated with various inflammatory illnesses. We therefore hypothesized that this TNF-α polymorphism would influence susceptibility to psychiatric symptoms during interferon alfa therapy. Methods: One hundred five patients with hepatitis C, initially without active major depression (major depressive disorder), were treated with interferon alfa and then prospectively monitored using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, the Beck Depression Inventory II, the Anger Irritability and Assault Questionnaire, and circulating TNF-α levels. The A-308G polymorphism (rs1800629) was determined using the 5′-nuclease assay. Repeated-measure mixed-effect analyses compared changes in symptoms over time. Result: Beck Depression Inventory II score increased during interferon alfa therapy (F = 6.2; P < 0.001), with 27% developing MDD. The TNF-α A allele was associated with worsened labile anger (F = 2.5; P < 0.05) and fatigue (F = 2.9; P < 0.05) during treatment but not with major depression incidence (χ2 = 0.0; P = 0.99) or increased Beck Depression Inventory II (F = 1.2; P = 0.31). Labile anger was not predicted by the serotonin transporter polymorphism (F = 0.8; P = 0.59). Discussion: During treatment with an exogenous cytokine, vulnerability to worsening labile anger-distinct from major depression-is associated with genetic variability in TNF-α. This has implications both for patients being treated with interferon alfa and our understanding of genetic vulnerability for different subtypes of dysphoric and mood disorders." @default.
• W2089260826 created "2016-06-24" @default.
• W2089260826 creator A5000921316 @default.
• W2089260826 creator A5016542452 @default.
• W2089260826 creator A5071539931 @default.
• W2089260826 creator A5086284606 @default.
• W2089260826 date "2010-07-01" @default.
• W2089260826 modified "2023-09-23" @default.
• W2089260826 title "Labile Anger During Interferon Alfa Treatment is Associated With a Polymorphism in Tumor Necrosis Factor α" @default.
• W2089260826 cites W133827248 @default.
• W2089260826 cites W1482709215 @default.
• W2089260826 cites W1532385548 @default.
• W2089260826 cites W1542136448 @default.
• W2089260826 cites W1548862642 @default.
• W2089260826 cites W1645475532 @default.
• W2089260826 cites W1964368905 @default.
• W2089260826 cites W1965657038 @default.
• W2089260826 cites W1968770452 @default.
• W2089260826 cites W1969065116 @default.
• W2089260826 cites W1972024018 @default.
• W2089260826 cites W1975490849 @default.
• W2089260826 cites W1978176455 @default.
• W2089260826 cites W1979000113 @default.
• W2089260826 cites W1980005387 @default.
• W2089260826 cites W1981024170 @default.
• W2089260826 cites W1983100921 @default.
• W2089260826 cites W1984030600 @default.
• W2089260826 cites W1986321526 @default.
• W2089260826 cites W1990097603 @default.
• W2089260826 cites W1990320054 @default.
• W2089260826 cites W1990806594 @default.
• W2089260826 cites W1996615918 @default.
• W2089260826 cites W1996678358 @default.
• W2089260826 cites W1998976706 @default.
• W2089260826 cites W2001864424 @default.
• W2089260826 cites W2002250647 @default.
• W2089260826 cites W2008779800 @default.
• W2089260826 cites W2011373732 @default.
• W2089260826 cites W2011493683 @default.
• W2089260826 cites W2011809148 @default.
• W2089260826 cites W2014472957 @default.
• W2089260826 cites W2018360542 @default.
• W2089260826 cites W2018896573 @default.
• W2089260826 cites W2020222089 @default.
• W2089260826 cites W2021673862 @default.
• W2089260826 cites W2021866048 @default.
• W2089260826 cites W2024038063 @default.
• W2089260826 cites W2027545702 @default.
• W2089260826 cites W2030164093 @default.
• W2089260826 cites W2030533607 @default.
• W2089260826 cites W2031871375 @default.
• W2089260826 cites W2034226072 @default.
• W2089260826 cites W2042701393 @default.
• W2089260826 cites W2043621175 @default.
• W2089260826 cites W2044649150 @default.
• W2089260826 cites W2052119995 @default.
• W2089260826 cites W2052139158 @default.
• W2089260826 cites W2053239117 @default.
• W2089260826 cites W2054741486 @default.
• W2089260826 cites W2055211617 @default.
• W2089260826 cites W2055241313 @default.
• W2089260826 cites W2055485744 @default.
• W2089260826 cites W2055712213 @default.
• W2089260826 cites W2056671248 @default.
• W2089260826 cites W2059793660 @default.
• W2089260826 cites W2060987103 @default.
• W2089260826 cites W2063175565 @default.
• W2089260826 cites W2064679409 @default.
• W2089260826 cites W2065948396 @default.
• W2089260826 cites W2066027939 @default.
• W2089260826 cites W2067855438 @default.
• W2089260826 cites W2068465151 @default.
• W2089260826 cites W2071238162 @default.
• W2089260826 cites W2071908428 @default.
• W2089260826 cites W2072833030 @default.
• W2089260826 cites W2073868632 @default.
• W2089260826 cites W2078994429 @default.
• W2089260826 cites W2081866521 @default.
• W2089260826 cites W2082733608 @default.
• W2089260826 cites W2083873586 @default.
• W2089260826 cites W2086208662 @default.
• W2089260826 cites W2086679559 @default.
• W2089260826 cites W2089327465 @default.
• W2089260826 cites W2091205696 @default.
• W2089260826 cites W2091262599 @default.
• W2089260826 cites W2092669597 @default.
• W2089260826 cites W2094525616 @default.
• W2089260826 cites W2096782296 @default.
• W2089260826 cites W2103150006 @default.
• W2089260826 cites W2108769690 @default.
• W2089260826 cites W2116797472 @default.
• W2089260826 cites W2116944267 @default.
• W2089260826 cites W2121573844 @default.
• W2089260826 cites W2127685726 @default.
• W2089260826 cites W2131650903 @default.
• W2089260826 cites W2142082128 @default.
• W2089260826 cites W2145135755 @default.
• W2089260826 cites W2151160099 @default.

• next