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• W2089261792 abstract "To determine the impact of intrathecal baclofen (ITB) therapy on outcomes of functional independence, pain, subjective improvement, performance, and standard measures of spasticity.A noncomparative, multicenter, prospective cohort trial of patients with implanted pumps followed up over a 12-month period for the assessment of spasticity, pain, and function.Twenty-four European centers of neurology or rehabilitation familiar with implantable pump technique participated.Patients with intractable spasticity (N=138) who responded positively to a trial dose of baclofen (n=133) and who began ITB therapy (n=129) were enrolled.Implantation of a Medtronic SynchroMed Infusion System with the administration of ITB therapy.Ashworth Scale assessment, Penn Spasm Frequency Scale scores, pain assessment, FIM instrument scores or WeeFIM scores for children, Canadian Occupational Performance Measure (COPM), and subjective ratings of overall relief were the tools administered.Muscle tone, spasm scores, and pain intensity reductions were observed. Overall FIM scores increased significantly in cognitive and motor function. COPM scores for both performance and satisfaction also improved significantly. Patients reported increased relief from pain and spasticity, supported by physician reports. Forty-three percent of patients reported adverse events, mostly related to patients' underlying conditions (20%), the device implant surgery (10%), or complications with the catheter (9%).ITB therapy using a programmable pump is clinically effective and well tolerated, despite a seemingly high level of adverse events, in patients with intractable spasticity of spinal or cerebral origin and may offer improvements in pain relief and function." @default.
• W2089261792 created "2016-06-24" @default.
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• W2089261792 date "2005-11-01" @default.
• W2089261792 modified "2023-10-13" @default.
• W2089261792 title "A Clinical Study of Intrathecal Baclofen Using a Programmable Pump for Intractable Spasticity" @default.
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• W2089261792 doi "https://doi.org/10.1016/j.apmr.2005.05.018" @default.
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