FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089270738> ?p ?o ?g. }

• W2089270738 endingPage "352" @default.
• W2089270738 startingPage "342" @default.
• W2089270738 abstract "Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis, and in mediating the action of the insulin sensitizing anti-diabetic thiazolidinedione (TZD) compounds. [3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3-H-benzimidazole-5-carboxamide] (FK614) is a structurally novel PPARγ agonist that demonstrates potent anti-diabetic activity in vivo. Herein, we describe that FK614 is a selective PPARγ ligand with specific transactivation properties that are dependent upon the context of coactivators. FK614 dissociates the corepressors NCoR (nuclear receptor corepressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors) from PPARγ as effectively as rosiglitazone and pioglitazone, but can also differentially induce a ligand specific interaction of PPARγ with coactivators. The amount of CBP (CREB-binding protein) and SRC-1 (steroid receptor coactivator-1) recruited by FK614 was less than that induced by rosiglitazone and pioglitazone, but FK614 caused similar PGC-1α (PPARγ coactivator-1α) recruitment as these compounds. As a consequence of these ligand-specific differences in the strength of ligand-type specific interactions of PPARγ and coactivators, FK614 functions as a partial or full agonist for transcriptional activation depending upon the amount of specific coactivators in cells following overexpression. In conclusion, FK614 is a novel, non-TZD type, and selective PPARγ modulator whose pharmacological properties are distinct from rosiglitazone and pioglitazone." @default.
• W2089270738 created "2016-06-24" @default.
• W2089270738 creator A5000950825 @default.
• W2089270738 creator A5001649070 @default.
• W2089270738 creator A5037429743 @default.
• W2089270738 creator A5058185011 @default.
• W2089270738 creator A5069286549 @default.
• W2089270738 creator A5069347835 @default.
• W2089270738 creator A5076947182 @default.
• W2089270738 creator A5080029736 @default.
• W2089270738 date "2005-01-01" @default.
• W2089270738 modified "2023-09-24" @default.
• W2089270738 title "FK614, a Novel Peroxisome Proliferator-Activated Receptor γ Modulator, Induces Differential Transactivation Through a Unique Ligand-Specific Interaction With Transcriptional Coactivators" @default.
• W2089270738 cites W1501286679 @default.
• W2089270738 cites W1527827101 @default.
• W2089270738 cites W1646199134 @default.
• W2089270738 cites W1969161886 @default.
• W2089270738 cites W1981101682 @default.
• W2089270738 cites W1983128420 @default.
• W2089270738 cites W1985063313 @default.
• W2089270738 cites W1991996819 @default.
• W2089270738 cites W1994489610 @default.
• W2089270738 cites W2006647733 @default.
• W2089270738 cites W2008632158 @default.
• W2089270738 cites W2020443182 @default.
• W2089270738 cites W2028026629 @default.
• W2089270738 cites W2033529039 @default.
• W2089270738 cites W2045389096 @default.
• W2089270738 cites W2047591801 @default.
• W2089270738 cites W2053765200 @default.
• W2089270738 cites W2063065419 @default.
• W2089270738 cites W2066073857 @default.
• W2089270738 cites W2066092624 @default.
• W2089270738 cites W2067096633 @default.
• W2089270738 cites W2068113812 @default.
• W2089270738 cites W2069532898 @default.
• W2089270738 cites W2078535741 @default.
• W2089270738 cites W2086376157 @default.
• W2089270738 cites W2087393295 @default.
• W2089270738 cites W2089235913 @default.
• W2089270738 cites W2101460040 @default.
• W2089270738 cites W2107752044 @default.
• W2089270738 cites W2137057476 @default.
• W2089270738 cites W2141918716 @default.
• W2089270738 cites W2143241514 @default.
• W2089270738 cites W2162178319 @default.
• W2089270738 cites W2164015929 @default.
• W2089270738 cites W4229958257 @default.
• W2089270738 cites W4238992151 @default.
• W2089270738 cites W4245165484 @default.
• W2089270738 cites W4254864035 @default.
• W2089270738 cites W91098912 @default.
• W2089270738 doi "https://doi.org/10.1254/jphs.fp0050578" @default.
• W2089270738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16314690" @default.
• W2089270738 hasPublicationYear "2005" @default.
• W2089270738 type Work @default.
• W2089270738 sameAs 2089270738 @default.
• W2089270738 citedByCount "38" @default.
• W2089270738 countsByYear W20892707382012 @default.
• W2089270738 countsByYear W20892707382013 @default.
• W2089270738 countsByYear W20892707382014 @default.
• W2089270738 countsByYear W20892707382016 @default.
• W2089270738 countsByYear W20892707382017 @default.
• W2089270738 countsByYear W20892707382018 @default.
• W2089270738 countsByYear W20892707382019 @default.
• W2089270738 countsByYear W20892707382021 @default.
• W2089270738 crossrefType "journal-article" @default.
• W2089270738 hasAuthorship W2089270738A5000950825 @default.
• W2089270738 hasAuthorship W2089270738A5001649070 @default.
• W2089270738 hasAuthorship W2089270738A5037429743 @default.
• W2089270738 hasAuthorship W2089270738A5058185011 @default.
• W2089270738 hasAuthorship W2089270738A5069286549 @default.
• W2089270738 hasAuthorship W2089270738A5069347835 @default.
• W2089270738 hasAuthorship W2089270738A5076947182 @default.
• W2089270738 hasAuthorship W2089270738A5080029736 @default.
• W2089270738 hasBestOaLocation W20892707381 @default.
• W2089270738 hasConcept C104317684 @default.
• W2089270738 hasConcept C109115496 @default.
• W2089270738 hasConcept C128821507 @default.
• W2089270738 hasConcept C1292079 @default.
• W2089270738 hasConcept C134018914 @default.
• W2089270738 hasConcept C146777309 @default.
• W2089270738 hasConcept C170493617 @default.
• W2089270738 hasConcept C185592680 @default.
• W2089270738 hasConcept C187345961 @default.
• W2089270738 hasConcept C195598365 @default.
• W2089270738 hasConcept C2776923340 @default.
• W2089270738 hasConcept C2777180221 @default.
• W2089270738 hasConcept C2778150266 @default.
• W2089270738 hasConcept C2778384471 @default.
• W2089270738 hasConcept C2778938600 @default.
• W2089270738 hasConcept C2780152017 @default.
• W2089270738 hasConcept C55493867 @default.
• W2089270738 hasConcept C555293320 @default.
• W2089270738 hasConcept C58732023 @default.
• W2089270738 hasConcept C63932345 @default.
• W2089270738 hasConcept C77445288 @default.
• W2089270738 hasConcept C86339819 @default.

• next