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- W2089274312 abstract "MicroRNAs (miRNAs) are small noncoding RNAs that regulate vast networks of genes that share miRNA target sequences. To examine the physiologic effects of an individual miRNA-mRNA interaction in vivo, we generated mice that carry a mutation in the putative microRNA-155 (miR-155) binding site in the 3′-untranslated region of activation-induced cytidine deaminase (AID), designated Aicda155 mice. AID is required for immunoglobulin gene diversification in B lymphocytes, but it also promotes chromosomal translocations. Aicda155 caused an increase in steady-state Aicda mRNA and protein amounts by increasing the half-life of the mRNA, resulting in a high degree of Myc-Igh translocations. A similar but more pronounced translocation phenotype was also found in miR-155-deficient mice. Our experiments indicate that miR-155 can act as a tumor suppressor by reducing potentially oncogenic translocations generated by AID." @default.
- W2089274312 created "2016-06-24" @default.
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- W2089274312 date "2008-05-01" @default.
- W2089274312 modified "2023-10-16" @default.
- W2089274312 title "MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation" @default.
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- W2089274312 doi "https://doi.org/10.1016/j.immuni.2008.04.002" @default.
- W2089274312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2713656" @default.
- W2089274312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18455451" @default.
- W2089274312 hasPublicationYear "2008" @default.
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