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• W2089319178 abstract "We assessed the effect of a 35-day delayed intracerebroventricular (ICV) infusion of epidermal growth factor (EGF) on the survival and function of the substantia nigra (SN) dopaminergic neurons after a unilateral mechanical transection of rat nigrostriatal pathway. EGF infusion for 28 days resulted in a twofold increase in the number of surviving tyrosine-hydroxylase (TH)–positive SN neurons and a significant increase in ipsilateral striatal TH-positive fiber staining compared to controls at 200 days following the injury. In addition, there was a persistent enhancement of behavioral recovery, as indicated by a reduction in amphetamine-induced rotations. We conclude that EGF exerts a neurotrophic effect on the dopaminergic neurons in this experimental model of parkinsonism." @default.
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• W2089319178 date "1991-01-01" @default.
• W2089319178 modified "2023-09-23" @default.
• W2089319178 title "Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats" @default.
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• W2089319178 doi "https://doi.org/10.1002/mds.870060403" @default.
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