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• W2089331767 startingPage "827" @default.
• W2089331767 abstract "To obtain definitive evidence that tau is a component of paired helical filaments (PHF) in Alzheimer's disease, we fractionated and sequenced PHF-derived peptides according to a previously described procedure. In the PHF digest, we found four independent tau peptides that were located in the carboxyl third of tau. Subsequent extensive analysis of the PHF digest did not provide any other tau peptides. The conventional PHF antiserum and a new antiserum directed toward formic acid-denatured PHF reacted with the distinct CNBr fragments of tau localized on the carboxy-terminal portion of tau by protein sequencing. From these observations, we conclude that the carboxyl third of tau is tightly bound to PHF." @default.
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• W2089331767 date "1988-11-01" @default.
• W2089331767 modified "2023-09-29" @default.
• W2089331767 title "The car☐yl third of tau is tightly bound to paired helical filaments" @default.
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• W2089331767 doi "https://doi.org/10.1016/0896-6273(88)90130-4" @default.
• W2089331767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2483105" @default.
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