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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089332050> ?p ?o ?g. }

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• W2089332050 abstract "Glypican 3 (GPC3), a GPI-anchored heparan sulfate proteoglycan, is expressed in the majority of hepatocellular carcinoma (HCC) tissues. Using MRL/lpr mice, we successfully generated a series of anti-GPC3 monoclonal antibodies (mAbs). GPC3 was partially cleaved between Arg358 and Ser359, generating a C-terminal 30-kDa fragment and an N-terminal 40-kDa fragment. All mAbs that induced antibody-dependent cellular cytotoxicity (ADCC) and/or complement-dependent cytotoxicity (CDC) against cells expressing GPC3 recognized the 30-kDa fragment, indicating that the C-terminal region of GPC3 serves as an epitope for mAb with ADCC and/or CDC inducing activities. Chimeric mAbs with Fc replaced by human IgG1 were created from GC33, one of the mAbs that reacted with the C-terminal 30-kDa fragment. Chimeric GC33 induced not only ADCC against GPC3-positive human HCC cells but also was efficacious against the Huh-7 human HCC xenograft. Thus, mAbs against the C-terminal 30-kDa fragment such as GC33 are useful in therapy targeting HCC." @default.
• W2089332050 created "2016-06-24" @default.
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• W2089332050 date "2009-01-01" @default.
• W2089332050 modified "2023-10-11" @default.
• W2089332050 title "Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells" @default.
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• W2089332050 doi "https://doi.org/10.1016/j.bbrc.2008.11.033" @default.
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