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• W2089332722 startingPage "14777" @default.
• W2089332722 abstract "Osteopontin (OPN), a multifunctional secreted phosphoglycoprotein, plays diverse roles in bone biology, immune regulation, cell survival, inflammation, and cancer metastasis. Here we show its role in determining lymphocyte homeostasis and body mass in response to hindlimb unloading (HU), a model for evaluating effects of weightlessness on the musculoskeletal and other physiological systems. Using this stress model, we compared OPN(-/-) mice with OPN(+/+) mice subjected to HU for 3 days. Whereas OPN(+/+) mice suffered a marked reduction of body weight and significant spleen and thymus atrophy, OPN(-/-) mice exhibited minor weight loss and much less spleen and thymus atrophy. The HU-induced lymphoid organ atrophy was the result of dramatically diminished numbers, respectively, of T and B cells in the spleen and CD4(+)CD8(+) double-positive cells in the thymus of OPN(+/+) mice. Increased levels of corticosterone, which modulates lymphocyte activation responses and apoptosis during stress, were found only in OPN(+/+) mice. Apoptotic cell death was evident in the spleen and thymus of OPN(+/+) mice subjected to HU but not in OPN(-/-)mice. Importantly, lymphocytes from both OPN(+/+) and OPN(-/-) mice were equally sensitive to corticosteroid-induced apoptosis. These results reveal that OPN is required for enhanced corticosterone production, immune organ atrophy, and weight loss in mice subjected to HU." @default.
• W2089332722 created "2016-06-24" @default.
• W2089332722 creator A5026346435 @default.
• W2089332722 creator A5027560531 @default.
• W2089332722 creator A5062682623 @default.
• W2089332722 date "2007-09-11" @default.
• W2089332722 modified "2023-10-15" @default.
• W2089332722 title "Osteopontin regulates hindlimb-unloading-induced lymphoid organ atrophy and weight loss by modulating corticosteroid production" @default.
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• W2089332722 doi "https://doi.org/10.1073/pnas.0703236104" @default.
• W2089332722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1976226" @default.
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• W2089332722 hasPublicationYear "2007" @default.
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