FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089338980> ?p ?o ?g. }

• W2089338980 endingPage "262" @default.
• W2089338980 startingPage "255" @default.
• W2089338980 abstract "It is known that steroid hormones can affect neuronal susceptibility to different types of insults, including oxidative stress. Using an in vitro/ex vivo model, we have previously shown that cerebellar granule cells prepared from neonatal rats treated with a single dose of testosterone are less vulnerable to oxidative stress-induced cell death, via a mechanism involving an upregulation of the cellular antioxidant defenses. Whether the testosterone protective action on cerebellar granule cells was direct or indirect remained to be clarified. Therefore, in this study we have investigated the effects of in vitro testosterone treatment, to see whether it also protects cerebellar granule cells from oxidative stress-induced damage. Cerebellar granule cells treated with 10(-6) M testosterone for 48 h were found less susceptible to damage induced by 50 microM hydrogen peroxide, as shown by a 30% decrease in the number of cells with apoptotic morphology. The addition of the androgen receptor antagonist flutamide abolished the protective effect of testosterone, suggesting an androgen receptor-mediated mechanism. This hypothesis was further supported by the presence of the androgen receptor in cultured cerebellar granule cells. The activity of the antioxidant enzyme catalase was also measured, and a 2-fold increase was detected in the testosterone treated cells, but not in the cells co-treated with flutamide. The present results demonstrate that cerebellar granule cells treated in vitro with testosterone are protected from oxidative stress via a mechanism mediated by the androgen receptor. Similarly to what we observed after in vivo administration of testosterone, the potentiation of the antioxidant defences seems to play a major role in the protection afforded by testosterone." @default.
• W2089338980 created "2016-06-24" @default.
• W2089338980 creator A5036769741 @default.
• W2089338980 creator A5041497192 @default.
• W2089338980 creator A5049719845 @default.
• W2089338980 date "2001-02-01" @default.
• W2089338980 modified "2023-09-30" @default.
• W2089338980 title "Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism" @default.
• W2089338980 cites W1542337165 @default.
• W2089338980 cites W1560125633 @default.
• W2089338980 cites W191793640 @default.
• W2089338980 cites W1963947734 @default.
• W2089338980 cites W1964726243 @default.
• W2089338980 cites W1964882593 @default.
• W2089338980 cites W1969280474 @default.
• W2089338980 cites W1977781211 @default.
• W2089338980 cites W1980248434 @default.
• W2089338980 cites W1988945933 @default.
• W2089338980 cites W1996434439 @default.
• W2089338980 cites W1996568613 @default.
• W2089338980 cites W2000758650 @default.
• W2089338980 cites W2002673255 @default.
• W2089338980 cites W2007004366 @default.
• W2089338980 cites W2008885463 @default.
• W2089338980 cites W2009948262 @default.
• W2089338980 cites W2021390728 @default.
• W2089338980 cites W2027515382 @default.
• W2089338980 cites W2031022721 @default.
• W2089338980 cites W2033027472 @default.
• W2089338980 cites W2037458498 @default.
• W2089338980 cites W2039457334 @default.
• W2089338980 cites W2044113906 @default.
• W2089338980 cites W2050581082 @default.
• W2089338980 cites W2052853635 @default.
• W2089338980 cites W2059358568 @default.
• W2089338980 cites W2063825250 @default.
• W2089338980 cites W2079355690 @default.
• W2089338980 cites W2080730559 @default.
• W2089338980 cites W2082294005 @default.
• W2089338980 cites W2082648762 @default.
• W2089338980 cites W2111344548 @default.
• W2089338980 cites W2111398489 @default.
• W2089338980 cites W2129902275 @default.
• W2089338980 cites W2136742966 @default.
• W2089338980 cites W2157187767 @default.
• W2089338980 cites W4240479615 @default.
• W2089338980 cites W4255064854 @default.
• W2089338980 doi "https://doi.org/10.1016/s0006-8993(00)03155-3" @default.
• W2089338980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11172772" @default.
• W2089338980 hasPublicationYear "2001" @default.
• W2089338980 type Work @default.
• W2089338980 sameAs 2089338980 @default.
• W2089338980 citedByCount "234" @default.
• W2089338980 countsByYear W20893389802012 @default.
• W2089338980 countsByYear W20893389802013 @default.
• W2089338980 countsByYear W20893389802014 @default.
• W2089338980 countsByYear W20893389802015 @default.
• W2089338980 countsByYear W20893389802016 @default.
• W2089338980 countsByYear W20893389802017 @default.
• W2089338980 countsByYear W20893389802018 @default.
• W2089338980 countsByYear W20893389802019 @default.
• W2089338980 countsByYear W20893389802020 @default.
• W2089338980 countsByYear W20893389802021 @default.
• W2089338980 countsByYear W20893389802022 @default.
• W2089338980 countsByYear W20893389802023 @default.
• W2089338980 crossrefType "journal-article" @default.
• W2089338980 hasAuthorship W2089338980A5036769741 @default.
• W2089338980 hasAuthorship W2089338980A5041497192 @default.
• W2089338980 hasAuthorship W2089338980A5049719845 @default.
• W2089338980 hasConcept C121608353 @default.
• W2089338980 hasConcept C126322002 @default.
• W2089338980 hasConcept C134018914 @default.
• W2089338980 hasConcept C151730666 @default.
• W2089338980 hasConcept C185592680 @default.
• W2089338980 hasConcept C2776151105 @default.
• W2089338980 hasConcept C2777911890 @default.
• W2089338980 hasConcept C2778313021 @default.
• W2089338980 hasConcept C2779652256 @default.
• W2089338980 hasConcept C2780192828 @default.
• W2089338980 hasConcept C49760210 @default.
• W2089338980 hasConcept C61367390 @default.
• W2089338980 hasConcept C71315377 @default.
• W2089338980 hasConcept C71924100 @default.
• W2089338980 hasConcept C86803240 @default.
• W2089338980 hasConceptScore W2089338980C121608353 @default.
• W2089338980 hasConceptScore W2089338980C126322002 @default.
• W2089338980 hasConceptScore W2089338980C134018914 @default.
• W2089338980 hasConceptScore W2089338980C151730666 @default.
• W2089338980 hasConceptScore W2089338980C185592680 @default.
• W2089338980 hasConceptScore W2089338980C2776151105 @default.
• W2089338980 hasConceptScore W2089338980C2777911890 @default.
• W2089338980 hasConceptScore W2089338980C2778313021 @default.
• W2089338980 hasConceptScore W2089338980C2779652256 @default.
• W2089338980 hasConceptScore W2089338980C2780192828 @default.
• W2089338980 hasConceptScore W2089338980C49760210 @default.
• W2089338980 hasConceptScore W2089338980C61367390 @default.
• W2089338980 hasConceptScore W2089338980C71315377 @default.
• W2089338980 hasConceptScore W2089338980C71924100 @default.

• next