Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089343039> ?p ?o ?g. }
- W2089343039 endingPage "1410" @default.
- W2089343039 startingPage "1401" @default.
- W2089343039 abstract "The development of an effective pharmacological countermeasure is needed to reduce the morbidity and mortality in military and civilian populations associated with possible exposure to ionizing radiation. We previously demonstrated that a single subcutaneous (sc) administration of genistein at a non-toxic dose provided protection against acute radiation injury and that the radioprotective effects were associated with multilineage, hematopoietic progenitor cell recovery. The purpose of this study was to determine whether hematopoietic recovery was preceded by cytokine induction. In mice treated with sc genistein 24 h before irradiation (7 Gy 60Co), we quantified serum cytokine levels by multiplex Luminex and also investigated a larger number of cytokines using cytokine arrays. Genistein administration stimulated serum granulocyte-colony stimulating factor (G-CSF) 4h and 24h after sham irradiation or gamma-irradiation. Interleukin-6 (IL-6) was significantly increased in genistein-treated animals 4h after irradiation. Because G-CSF and IL-6 are important hematopoietic factors, these results support our hypothesis that the previously observed radioprotective efficacy by genistein may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and IL-6." @default.
- W2089343039 created "2016-06-24" @default.
- W2089343039 creator A5000322586 @default.
- W2089343039 creator A5030764726 @default.
- W2089343039 creator A5036039110 @default.
- W2089343039 creator A5073068006 @default.
- W2089343039 creator A5090518047 @default.
- W2089343039 date "2009-11-01" @default.
- W2089343039 modified "2023-10-02" @default.
- W2089343039 title "Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice" @default.
- W2089343039 cites W1483959577 @default.
- W2089343039 cites W1602618889 @default.
- W2089343039 cites W1693873790 @default.
- W2089343039 cites W1939905704 @default.
- W2089343039 cites W1965757608 @default.
- W2089343039 cites W1969354851 @default.
- W2089343039 cites W1970813359 @default.
- W2089343039 cites W1971320471 @default.
- W2089343039 cites W1973033637 @default.
- W2089343039 cites W1988463112 @default.
- W2089343039 cites W1989147755 @default.
- W2089343039 cites W1992123604 @default.
- W2089343039 cites W1998228931 @default.
- W2089343039 cites W2002215035 @default.
- W2089343039 cites W2007292828 @default.
- W2089343039 cites W2013698997 @default.
- W2089343039 cites W2016033405 @default.
- W2089343039 cites W2026443172 @default.
- W2089343039 cites W2028442047 @default.
- W2089343039 cites W2031244557 @default.
- W2089343039 cites W2035505806 @default.
- W2089343039 cites W2043881251 @default.
- W2089343039 cites W2045027597 @default.
- W2089343039 cites W2045211890 @default.
- W2089343039 cites W2049363137 @default.
- W2089343039 cites W2054844477 @default.
- W2089343039 cites W2057705659 @default.
- W2089343039 cites W2061379581 @default.
- W2089343039 cites W2070911631 @default.
- W2089343039 cites W2073232463 @default.
- W2089343039 cites W2075115082 @default.
- W2089343039 cites W2086724435 @default.
- W2089343039 cites W2088236232 @default.
- W2089343039 cites W2090329397 @default.
- W2089343039 cites W2100596421 @default.
- W2089343039 cites W2103486381 @default.
- W2089343039 cites W2114196865 @default.
- W2089343039 cites W2121603625 @default.
- W2089343039 cites W2128348419 @default.
- W2089343039 cites W2133150521 @default.
- W2089343039 cites W2147606309 @default.
- W2089343039 cites W2159030449 @default.
- W2089343039 cites W2161619307 @default.
- W2089343039 cites W2164973714 @default.
- W2089343039 cites W2169776852 @default.
- W2089343039 cites W2170124346 @default.
- W2089343039 cites W2270245312 @default.
- W2089343039 cites W2288110886 @default.
- W2089343039 cites W2294567021 @default.
- W2089343039 cites W2298584763 @default.
- W2089343039 cites W2337652704 @default.
- W2089343039 cites W2397734749 @default.
- W2089343039 cites W2911273765 @default.
- W2089343039 cites W37982937 @default.
- W2089343039 cites W4247442762 @default.
- W2089343039 cites W4294216491 @default.
- W2089343039 doi "https://doi.org/10.1016/j.intimp.2009.08.012" @default.
- W2089343039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19716438" @default.
- W2089343039 hasPublicationYear "2009" @default.
- W2089343039 type Work @default.
- W2089343039 sameAs 2089343039 @default.
- W2089343039 citedByCount "49" @default.
- W2089343039 countsByYear W20893430392012 @default.
- W2089343039 countsByYear W20893430392013 @default.
- W2089343039 countsByYear W20893430392014 @default.
- W2089343039 countsByYear W20893430392015 @default.
- W2089343039 countsByYear W20893430392016 @default.
- W2089343039 countsByYear W20893430392017 @default.
- W2089343039 countsByYear W20893430392018 @default.
- W2089343039 countsByYear W20893430392019 @default.
- W2089343039 countsByYear W20893430392020 @default.
- W2089343039 countsByYear W20893430392021 @default.
- W2089343039 countsByYear W20893430392022 @default.
- W2089343039 countsByYear W20893430392023 @default.
- W2089343039 crossrefType "journal-article" @default.
- W2089343039 hasAuthorship W2089343039A5000322586 @default.
- W2089343039 hasAuthorship W2089343039A5030764726 @default.
- W2089343039 hasAuthorship W2089343039A5036039110 @default.
- W2089343039 hasAuthorship W2089343039A5073068006 @default.
- W2089343039 hasAuthorship W2089343039A5090518047 @default.
- W2089343039 hasConcept C109159458 @default.
- W2089343039 hasConcept C126322002 @default.
- W2089343039 hasConcept C203014093 @default.
- W2089343039 hasConcept C2776390293 @default.
- W2089343039 hasConcept C2776694085 @default.
- W2089343039 hasConcept C2777478134 @default.
- W2089343039 hasConcept C2777767877 @default.
- W2089343039 hasConcept C2778298627 @default.