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• W2089351538 abstract "Nineteen new derivatives based on the structure of marine natural product tasiamide B were designed, synthesized, and evaluated for their inhibitory activity against BACE1, a potential therapeutic target for Alzheimer's disease. The hydrophobic substituents Val at P₃ position, Leu at P₁' position, Ala at P₂' position, and Phe at P₃' position were found to significantly affect the inhibition. Free carboxylic acid at C-terminus was also found to be important to the activity. In addition, the structure-activity relationships (SARs) were supported by molecular docking simulation." @default.
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• W2089351538 date "2015-05-01" @default.
• W2089351538 modified "2023-10-15" @default.
• W2089351538 title "Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors" @default.
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• W2089351538 doi "https://doi.org/10.1016/j.bmc.2015.03.034" @default.
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