Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089352007> ?p ?o ?g. }
- W2089352007 endingPage "334" @default.
- W2089352007 startingPage "325" @default.
- W2089352007 abstract "Abstract: The main metabolites of remoxipride formed in rat and man were examined for their affinities for the [3H] SCH 23390-labelled DA D1 and [3H]-raclopride-labelled D2 receptors in rat striatal homogenates. In addition, their effectiveness in blocking postsynaptic DA receptor activity in vivo was measured by the use of several different test models in the male rat. Phenolic metabolites formed mainly in the rat retained (similar to remoxipride) their selectivity for the D2 receptor with very low affinities for the D1 receptor. The pyrrolidone metabolites formed mainly in man showed very low affinities for both the D1 and D2 receptors. The ability of the metabolites to block postsynaptic DA receptor activity in vivo correlated with their affinities for the D2 receptor. Among the metabolites tested, the phenolic compounds FLA 797 (–) and FLA 908 (–) were much more effective than remoxipride in inducing catalepsy, which is consistent with a higher affinity for [3H] raclopride labelled striatal D2 receptors. However, analysis of the effectiveness of the DA receptor blockade (blockade of d-amphetamine locomotion or DA agonist hypothermia) after intraperitoneal or subcutaneous administration suggested that FLA 797 (–)/FLA 908 (–) may only contribute marginally to the D2 receptor-blocking activity of remoxipride in the rat. This conclusion was further supported by the observation that the atypical antipsychotic profile of remoxipride was not mimicked by the active metabolites. The weak DA D2 blocking effect of the pyrrolidone metabolites indicated that remoxipride is responsible for the clinical action." @default.
- W2089352007 created "2016-06-24" @default.
- W2089352007 creator A5005478132 @default.
- W2089352007 creator A5032742289 @default.
- W2089352007 creator A5039975658 @default.
- W2089352007 creator A5067222102 @default.
- W2089352007 date "1993-12-01" @default.
- W2089352007 modified "2023-10-15" @default.
- W2089352007 title "Effects of Remoxipride's Metabolites on Dopamine D2Receptors and Receptor Functions in the Rat" @default.
- W2089352007 cites W1964204546 @default.
- W2089352007 cites W1966092598 @default.
- W2089352007 cites W1972979592 @default.
- W2089352007 cites W1978885695 @default.
- W2089352007 cites W1983245593 @default.
- W2089352007 cites W1992061616 @default.
- W2089352007 cites W2010700904 @default.
- W2089352007 cites W2018764772 @default.
- W2089352007 cites W2022395708 @default.
- W2089352007 cites W2023770577 @default.
- W2089352007 cites W2033910397 @default.
- W2089352007 cites W2040844884 @default.
- W2089352007 cites W2043813981 @default.
- W2089352007 cites W2043881516 @default.
- W2089352007 cites W2044706500 @default.
- W2089352007 cites W2051077097 @default.
- W2089352007 cites W2055273921 @default.
- W2089352007 cites W2056553920 @default.
- W2089352007 cites W2057788173 @default.
- W2089352007 cites W2059230444 @default.
- W2089352007 cites W2061131681 @default.
- W2089352007 cites W2064853843 @default.
- W2089352007 cites W2067330736 @default.
- W2089352007 cites W2073711860 @default.
- W2089352007 cites W2080636204 @default.
- W2089352007 cites W2127087784 @default.
- W2089352007 cites W2164298318 @default.
- W2089352007 cites W2330759546 @default.
- W2089352007 cites W93075821 @default.
- W2089352007 doi "https://doi.org/10.1111/j.1600-0773.1993.tb01360.x" @default.
- W2089352007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8153056" @default.
- W2089352007 hasPublicationYear "1993" @default.
- W2089352007 type Work @default.
- W2089352007 sameAs 2089352007 @default.
- W2089352007 citedByCount "6" @default.
- W2089352007 crossrefType "journal-article" @default.
- W2089352007 hasAuthorship W2089352007A5005478132 @default.
- W2089352007 hasAuthorship W2089352007A5032742289 @default.
- W2089352007 hasAuthorship W2089352007A5039975658 @default.
- W2089352007 hasAuthorship W2089352007A5067222102 @default.
- W2089352007 hasConcept C134018914 @default.
- W2089352007 hasConcept C150903083 @default.
- W2089352007 hasConcept C170493617 @default.
- W2089352007 hasConcept C185592680 @default.
- W2089352007 hasConcept C207001950 @default.
- W2089352007 hasConcept C2778938600 @default.
- W2089352007 hasConcept C2779917531 @default.
- W2089352007 hasConcept C2780476085 @default.
- W2089352007 hasConcept C2780948584 @default.
- W2089352007 hasConcept C2781069445 @default.
- W2089352007 hasConcept C44208683 @default.
- W2089352007 hasConcept C513476851 @default.
- W2089352007 hasConcept C55493867 @default.
- W2089352007 hasConcept C86803240 @default.
- W2089352007 hasConcept C98274493 @default.
- W2089352007 hasConceptScore W2089352007C134018914 @default.
- W2089352007 hasConceptScore W2089352007C150903083 @default.
- W2089352007 hasConceptScore W2089352007C170493617 @default.
- W2089352007 hasConceptScore W2089352007C185592680 @default.
- W2089352007 hasConceptScore W2089352007C207001950 @default.
- W2089352007 hasConceptScore W2089352007C2778938600 @default.
- W2089352007 hasConceptScore W2089352007C2779917531 @default.
- W2089352007 hasConceptScore W2089352007C2780476085 @default.
- W2089352007 hasConceptScore W2089352007C2780948584 @default.
- W2089352007 hasConceptScore W2089352007C2781069445 @default.
- W2089352007 hasConceptScore W2089352007C44208683 @default.
- W2089352007 hasConceptScore W2089352007C513476851 @default.
- W2089352007 hasConceptScore W2089352007C55493867 @default.
- W2089352007 hasConceptScore W2089352007C86803240 @default.
- W2089352007 hasConceptScore W2089352007C98274493 @default.
- W2089352007 hasIssue "6" @default.
- W2089352007 hasLocation W20893520071 @default.
- W2089352007 hasLocation W20893520072 @default.
- W2089352007 hasOpenAccess W2089352007 @default.
- W2089352007 hasPrimaryLocation W20893520071 @default.
- W2089352007 hasRelatedWork W1608852546 @default.
- W2089352007 hasRelatedWork W2031472570 @default.
- W2089352007 hasRelatedWork W2039830165 @default.
- W2089352007 hasRelatedWork W2055810738 @default.
- W2089352007 hasRelatedWork W2065267327 @default.
- W2089352007 hasRelatedWork W2074760186 @default.
- W2089352007 hasRelatedWork W2075515027 @default.
- W2089352007 hasRelatedWork W2136741784 @default.
- W2089352007 hasRelatedWork W2268914673 @default.
- W2089352007 hasRelatedWork W2411040444 @default.
- W2089352007 hasVolume "73" @default.
- W2089352007 isParatext "false" @default.
- W2089352007 isRetracted "false" @default.
- W2089352007 magId "2089352007" @default.