FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089367177> ?p ?o ?g. }

• W2089367177 endingPage "1170" @default.
• W2089367177 startingPage "1162" @default.
• W2089367177 abstract "Cytoplasmic dynein is recruited to the cell cortex in early mitosis, where it can generate pulling forces on astral microtubules to position the mitotic spindle. Recent work has shown that dynein displays a dynamic asymmetric cortical localization, and that dynein recruitment is negatively regulated by spindle pole-proximity. This results in oscillating dynein recruitment to opposite sides of the cortex to center the mitotic spindle. However, although the centrosome-derived signal that promotes displacement of dynein has been identified, it is currently unknown how dynein is re-recruited to the cortex once it has been displaced. Here we show that re-recruitment of cortical dynein requires astral microtubules. We find that microtubules are necessary for the sustained localized enrichment of dynein at the cortex. Furthermore, we show that stabilization of astral microtubules causes spindle misorientation, followed by mispositioning of dynein at the cortex. Thus, our results demonstrate the importance of astral microtubules in the dynamic regulation of cortical dynein recruitment in mitosis." @default.
• W2089367177 created "2016-06-24" @default.
• W2089367177 creator A5014165324 @default.
• W2089367177 creator A5019907039 @default.
• W2089367177 creator A5020180105 @default.
• W2089367177 creator A5022915602 @default.
• W2089367177 creator A5074565662 @default.
• W2089367177 creator A5078914963 @default.
• W2089367177 date "2014-02-10" @default.
• W2089367177 modified "2023-10-10" @default.
• W2089367177 title "Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning" @default.
• W2089367177 cites W1944415070 @default.
• W2089367177 cites W1965256428 @default.
• W2089367177 cites W1972508744 @default.
• W2089367177 cites W1973127857 @default.
• W2089367177 cites W1973756205 @default.
• W2089367177 cites W1974059924 @default.
• W2089367177 cites W1975022818 @default.
• W2089367177 cites W1977416347 @default.
• W2089367177 cites W1985725667 @default.
• W2089367177 cites W1988573682 @default.
• W2089367177 cites W1996888932 @default.
• W2089367177 cites W2001200852 @default.
• W2089367177 cites W2005218158 @default.
• W2089367177 cites W2007496445 @default.
• W2089367177 cites W2008814168 @default.
• W2089367177 cites W2024686059 @default.
• W2089367177 cites W2031811488 @default.
• W2089367177 cites W2034301798 @default.
• W2089367177 cites W2038516595 @default.
• W2089367177 cites W2038970717 @default.
• W2089367177 cites W2041158925 @default.
• W2089367177 cites W2042288505 @default.
• W2089367177 cites W2044668046 @default.
• W2089367177 cites W2045843159 @default.
• W2089367177 cites W2049469649 @default.
• W2089367177 cites W2054836163 @default.
• W2089367177 cites W2055613399 @default.
• W2089367177 cites W2066190107 @default.
• W2089367177 cites W2072443704 @default.
• W2089367177 cites W2073557891 @default.
• W2089367177 cites W2076552007 @default.
• W2089367177 cites W2078146767 @default.
• W2089367177 cites W2081589050 @default.
• W2089367177 cites W2082905899 @default.
• W2089367177 cites W2083034193 @default.
• W2089367177 cites W2086566704 @default.
• W2089367177 cites W2089080652 @default.
• W2089367177 cites W2093702766 @default.
• W2089367177 cites W2095435423 @default.
• W2089367177 cites W2097664711 @default.
• W2089367177 cites W2107365045 @default.
• W2089367177 cites W2108590463 @default.
• W2089367177 cites W2109977719 @default.
• W2089367177 cites W2115850825 @default.
• W2089367177 cites W2120891538 @default.
• W2089367177 cites W2128647989 @default.
• W2089367177 cites W2130217713 @default.
• W2089367177 cites W2137736681 @default.
• W2089367177 cites W2143456993 @default.
• W2089367177 cites W2149151220 @default.
• W2089367177 cites W2152399358 @default.
• W2089367177 cites W2152422855 @default.
• W2089367177 cites W2152969835 @default.
• W2089367177 cites W2153456712 @default.
• W2089367177 cites W2157319245 @default.
• W2089367177 cites W2158633069 @default.
• W2089367177 cites W2160700935 @default.
• W2089367177 cites W2171939937 @default.
• W2089367177 cites W4246573955 @default.
• W2089367177 doi "https://doi.org/10.4161/cc.28031" @default.
• W2089367177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4013166" @default.
• W2089367177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24553118" @default.
• W2089367177 hasPublicationYear "2014" @default.
• W2089367177 type Work @default.
• W2089367177 sameAs 2089367177 @default.
• W2089367177 citedByCount "30" @default.
• W2089367177 countsByYear W20893671772015 @default.
• W2089367177 countsByYear W20893671772016 @default.
• W2089367177 countsByYear W20893671772017 @default.
• W2089367177 countsByYear W20893671772018 @default.
• W2089367177 countsByYear W20893671772019 @default.
• W2089367177 countsByYear W20893671772020 @default.
• W2089367177 countsByYear W20893671772021 @default.
• W2089367177 countsByYear W20893671772022 @default.
• W2089367177 crossrefType "journal-article" @default.
• W2089367177 hasAuthorship W2089367177A5014165324 @default.
• W2089367177 hasAuthorship W2089367177A5019907039 @default.
• W2089367177 hasAuthorship W2089367177A5020180105 @default.
• W2089367177 hasAuthorship W2089367177A5022915602 @default.
• W2089367177 hasAuthorship W2089367177A5074565662 @default.
• W2089367177 hasAuthorship W2089367177A5078914963 @default.
• W2089367177 hasBestOaLocation W20893671771 @default.
• W2089367177 hasConcept C10447061 @default.
• W2089367177 hasConcept C106987784 @default.
• W2089367177 hasConcept C134729014 @default.
• W2089367177 hasConcept C142669718 @default.
• W2089367177 hasConcept C1491633281 @default.

• next