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- W2089385251 abstract "Abstract. Plasma lecithin cholesterol acyltranaf erase (LCAT) activity was found to be significantly reduced in patients with intestinal malabsorption. Despite this the proportion of esterified cholesterol in plasma was relatively normal. LCAT activity was correlated with the amount of cholesterol carried in high density lipoproteins (HDL) but not with whole plasma cholesterol. Plasma from the patients with malabsorption appeared to be as effective a substrate for a “standard” LCAT source as control plasma, and administration of Intralipid to replenish the reduced proportion of linoleic acid in plasma lecithin did not improve the efficacy of malabsorber plasma as an LCAT substrate. Treatment of patients with pernicious anaemia with vitamin B12 was followed by marked increases in plasma concentrations of free and ester cholesterol and also in plasma LCAT activity, but there was relatively little change in the proportion of the plasma cholesterol which was esterified.—The results are compatible with the hypothesis that the concentration of free cholesterol in plasma, or some related variable, is a determinant of circulating LCAT activity." @default.
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- W2089385251 date "1973-10-01" @default.
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- W2089385251 title "Plasma Cholesterol Esterification in Patients with Secondary Hypocholesterolaemia" @default.
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- W2089385251 doi "https://doi.org/10.1111/j.1365-2362.1973.tb02207.x" @default.
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