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• W2089408029 abstract "Melanin-concentrating hormone (MCH) neurons and MCH-1 receptors (MCH1r) densely populate mesolimbic dopaminergic brain regions such as the nucleus accumbens (NAc). The regulation of dopamine by MCH1r was suggested to be an important mechanism underlying the hyperactive phenotype of MCH1r knock-out (ko) mice. However, MCH1r modulation of monoamine neurotransmission has yet to be examined. We tested whether dopamine, norepinephrine, and serotonin function is dysregulated in MCH1r ko and wild-type (wt) mice. MCH1r ko mice exhibited robust hyperactivity in a novel or familiar environment and were super-sensitive to the locomotor activating effects of d -amphetamine and the D 1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benazepine HCl. The D 2 agonist, quinpirole, decreased locomotion similarly in both ko and wt mice. Tissue contents of dopamine within the NAc and caudate-putamen were not significantly different in ko compared with wt mice. Basal and amphetamine-evoked NAc dopamine, norepinephrine, and serotonin efflux, as measured using in vivo microdialysis, were not significantly different between genotypes. In contrast, D 1 -like and D 2 -like receptor binding were significantly higher within the olfactory tubercle, ventral tegmental area, and NAc core and shell of ko mice. Norepinephrine transporter (NET) binding was significantly elevated within the NAc shell and globus pallidus of ko mice, whereas serotonin transporter binding was decreased in the NAc shell. Thus, deletion of MCH1r results in an upregulation of mesolimbic dopamine receptors and NET, indicating that MCH1r may negatively modulate mesolimbic monoamine function. MCH1r may be an important therapeutic target for neuropsychiatric disorders involving dysregulation of limbic monoamine systems." @default.
• W2089408029 created "2016-06-24" @default.
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• W2089408029 date "2005-01-26" @default.
• W2089408029 modified "2023-10-11" @default.
• W2089408029 title "Mesolimbic Dopamine Super-Sensitivity in Melanin-Concentrating Hormone-1 Receptor-Deficient Mice" @default.
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• W2089408029 cites W1503918021 @default.
• W2089408029 cites W1625842445 @default.
• W2089408029 cites W1895466054 @default.
• W2089408029 cites W1925421377 @default.
• W2089408029 cites W1970541082 @default.
• W2089408029 cites W1978082185 @default.
• W2089408029 cites W1978245181 @default.
• W2089408029 cites W1979616143 @default.
• W2089408029 cites W1980501557 @default.
• W2089408029 cites W1983627599 @default.
• W2089408029 cites W1986685236 @default.
• W2089408029 cites W1993137505 @default.
• W2089408029 cites W1993807996 @default.
• W2089408029 cites W2002766201 @default.
• W2089408029 cites W2003973769 @default.
• W2089408029 cites W2004159929 @default.
• W2089408029 cites W2004905652 @default.
• W2089408029 cites W2005452242 @default.
• W2089408029 cites W2005657014 @default.
• W2089408029 cites W2009189044 @default.
• W2089408029 cites W2014793858 @default.
• W2089408029 cites W2018089787 @default.
• W2089408029 cites W2019510335 @default.
• W2089408029 cites W2021136943 @default.
• W2089408029 cites W2021223587 @default.
• W2089408029 cites W2023368498 @default.
• W2089408029 cites W2031723027 @default.
• W2089408029 cites W2035486944 @default.
• W2089408029 cites W2036398723 @default.
• W2089408029 cites W2040668666 @default.
• W2089408029 cites W2041404902 @default.
• W2089408029 cites W2041889311 @default.
• W2089408029 cites W2043835965 @default.
• W2089408029 cites W2046336824 @default.
• W2089408029 cites W2058744011 @default.
• W2089408029 cites W2061161259 @default.
• W2089408029 cites W2064453868 @default.
• W2089408029 cites W2067136906 @default.
• W2089408029 cites W2069309932 @default.
• W2089408029 cites W2073131945 @default.
• W2089408029 cites W2082988068 @default.
• W2089408029 cites W2085674390 @default.
• W2089408029 cites W2092400229 @default.
• W2089408029 cites W2092565590 @default.
• W2089408029 cites W2093566337 @default.
• W2089408029 cites W2094554392 @default.
• W2089408029 cites W2102050521 @default.
• W2089408029 cites W2102590502 @default.
• W2089408029 cites W2111031293 @default.
• W2089408029 cites W2117480181 @default.
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• W2089408029 cites W2126122751 @default.
• W2089408029 cites W2126543187 @default.
• W2089408029 cites W2127905906 @default.
• W2089408029 cites W2127946577 @default.
• W2089408029 cites W2135007894 @default.
• W2089408029 cites W2145533695 @default.
• W2089408029 cites W2145718676 @default.
• W2089408029 cites W2147289447 @default.
• W2089408029 cites W2160442886 @default.
• W2089408029 cites W2166745166 @default.
• W2089408029 cites W2172187127 @default.
• W2089408029 cites W2232667923 @default.
• W2089408029 cites W2302997617 @default.
• W2089408029 cites W2425527909 @default.
• W2089408029 cites W4232333102 @default.
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• W2089408029 doi "https://doi.org/10.1523/jneurosci.4079-04.2005" @default.
• W2089408029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6725636" @default.
• W2089408029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15673672" @default.
• W2089408029 hasPublicationYear "2005" @default.
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