FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089412156> ?p ?o ?g. }

• W2089412156 endingPage "244" @default.
• W2089412156 startingPage "231" @default.
• W2089412156 abstract "Introduction: The greatest advantage of using microfluidics as a platform for the assessment of cardiovascular drug action is its ability to finely regulate fluid flow conditions, including flow rate, shear stress and pulsatile flow. At the same time, microfluidics provide means for modifying the vessel geometry (bifurcations, stenoses, complex networks), the type of surface of the vessel walls, and for patterning cells in 3D tissue-like architecture, including generation of lumen walls lined with cells and heart-on-a-chip structures for mimicking ventricular cardiomyocyte physiology. In addition, owing to the small volume of required specimens, microfluidics is ideally suited to clinical situations whereby monitoring of drug dosing or efficacy needs to be coupled with minimal phlebotomy-related drug loss.Areas covered: In this review, the authors highlight potential applications for the currently existing and emerging technologies and offer several suggestions on how to close the development cycle of microfluidic devices for cardiovascular drug discovery.Expert opinion: The ultimate goal in microfluidics research for drug discovery is to develop ‘human-on-a-chip’ systems, whereby several organ cultures, including the vasculature and the heart, can mimic complex interactions between the organs and body systems. This would provide in vivo-like pharmacokinetics and pharmacodynamics for drug ADMET assessment. At present, however, the great variety of available designs does not go hand in hand with their use by the pharmaceutical community." @default.
• W2089412156 created "2016-06-24" @default.
• W2089412156 creator A5035959270 @default.
• W2089412156 creator A5067821674 @default.
• W2089412156 date "2015-02-11" @default.
• W2089412156 modified "2023-09-25" @default.
• W2089412156 title "Successes and future outlook for microfluidics-based cardiovascular drug discovery" @default.
• W2089412156 cites W1514362376 @default.
• W2089412156 cites W1581553688 @default.
• W2089412156 cites W1964747869 @default.
• W2089412156 cites W1972865229 @default.
• W2089412156 cites W1981030985 @default.
• W2089412156 cites W1981664235 @default.
• W2089412156 cites W1982228392 @default.
• W2089412156 cites W1987908931 @default.
• W2089412156 cites W1993045733 @default.
• W2089412156 cites W1995389406 @default.
• W2089412156 cites W1996282847 @default.
• W2089412156 cites W1998018855 @default.
• W2089412156 cites W2000970397 @default.
• W2089412156 cites W2001531368 @default.
• W2089412156 cites W2006045700 @default.
• W2089412156 cites W2006153493 @default.
• W2089412156 cites W2010487285 @default.
• W2089412156 cites W2012016215 @default.
• W2089412156 cites W2013520568 @default.
• W2089412156 cites W2014537724 @default.
• W2089412156 cites W2020176159 @default.
• W2089412156 cites W2022237041 @default.
• W2089412156 cites W2023313128 @default.
• W2089412156 cites W2024186086 @default.
• W2089412156 cites W2024350787 @default.
• W2089412156 cites W2025745303 @default.
• W2089412156 cites W2025835293 @default.
• W2089412156 cites W2028430054 @default.
• W2089412156 cites W2034371538 @default.
• W2089412156 cites W2034921547 @default.
• W2089412156 cites W2035844219 @default.
• W2089412156 cites W2035903849 @default.
• W2089412156 cites W2036894989 @default.
• W2089412156 cites W2045889911 @default.
• W2089412156 cites W2047570670 @default.
• W2089412156 cites W2048526255 @default.
• W2089412156 cites W2059785926 @default.
• W2089412156 cites W2062995790 @default.
• W2089412156 cites W2064019624 @default.
• W2089412156 cites W2065257811 @default.
• W2089412156 cites W2065593094 @default.
• W2089412156 cites W2067214401 @default.
• W2089412156 cites W2067361031 @default.
• W2089412156 cites W2070244277 @default.
• W2089412156 cites W2072745088 @default.
• W2089412156 cites W2076922024 @default.
• W2089412156 cites W2083166046 @default.
• W2089412156 cites W2083507739 @default.
• W2089412156 cites W2085849664 @default.
• W2089412156 cites W2085971802 @default.
• W2089412156 cites W2086925927 @default.
• W2089412156 cites W2089704822 @default.
• W2089412156 cites W2090136117 @default.
• W2089412156 cites W2091000913 @default.
• W2089412156 cites W2091551811 @default.
• W2089412156 cites W2092303854 @default.
• W2089412156 cites W2093377746 @default.
• W2089412156 cites W2093960436 @default.
• W2089412156 cites W2094576343 @default.
• W2089412156 cites W2095921273 @default.
• W2089412156 cites W2096372947 @default.
• W2089412156 cites W2102075858 @default.
• W2089412156 cites W2109139627 @default.
• W2089412156 cites W2111853718 @default.
• W2089412156 cites W2117397508 @default.
• W2089412156 cites W2119638450 @default.
• W2089412156 cites W2126275439 @default.
• W2089412156 cites W2135961866 @default.
• W2089412156 cites W2142566812 @default.
• W2089412156 cites W2145258540 @default.
• W2089412156 cites W2147320720 @default.
• W2089412156 cites W2155883485 @default.
• W2089412156 cites W2156395575 @default.
• W2089412156 cites W2160386701 @default.
• W2089412156 cites W2163307683 @default.
• W2089412156 cites W2188573175 @default.
• W2089412156 cites W2220390677 @default.
• W2089412156 cites W2329648100 @default.
• W2089412156 cites W2409883011 @default.
• W2089412156 doi "https://doi.org/10.1517/17460441.2015.1001736" @default.
• W2089412156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25672221" @default.
• W2089412156 hasPublicationYear "2015" @default.
• W2089412156 type Work @default.
• W2089412156 sameAs 2089412156 @default.
• W2089412156 citedByCount "26" @default.
• W2089412156 countsByYear W20894121562015 @default.
• W2089412156 countsByYear W20894121562016 @default.
• W2089412156 countsByYear W20894121562017 @default.
• W2089412156 countsByYear W20894121562018 @default.
• W2089412156 countsByYear W20894121562019 @default.
• W2089412156 countsByYear W20894121562020 @default.

• next