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- W2089430956 endingPage "e49995" @default.
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- W2089430956 abstract "Objective Low back pain is associated with lumbar disc degeneration, which is mainly due to genetic predisposition. The objective of this study was to perform a systematic review to evaluate genetic association studies in lumbar disc degeneration as defined on magnetic resonance imaging (MRI) in humans. Methods A systematic literature search was conducted in MEDLINE, MEDLINE In-Process, SCOPUS, ISI Web of Science, The Genetic Association Database and The Human Genome Epidemiology Network for information published between 1990–2011 addressing genes and lumbar disc degeneration. Two investigators independently identified studies to determine inclusion, after which they performed data extraction and analysis. The level of cumulative genetic association evidence was analyzed according to The HuGENet Working Group guidelines. Results Fifty-two studies were included for review. Forty-eight studies reported at least one positive association between a genetic marker and lumbar disc degeneration. The phenotype definition of lumbar disc degeneration was highly variable between the studies and replications were inconsistent. Most of the associations presented with a weak level of evidence. The level of evidence was moderate for ASPN (D-repeat), COL11A1 (rs1676486), GDF5 (rs143383), SKT (rs16924573), THBS2 (rs9406328) and MMP9 (rs17576). Conclusions Based on this first extensive systematic review on the topic, the credibility of reported genetic associations is mostly weak. Clear definition of lumbar disc degeneration phenotypes and large population-based cohorts are needed. An international consortium is needed to standardize genetic association studies in relation to disc degeneration." @default.
- W2089430956 created "2016-06-24" @default.
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- W2089430956 date "2012-11-21" @default.
- W2089430956 modified "2023-10-01" @default.
- W2089430956 title "Genetic Association Studies in Lumbar Disc Degeneration: A Systematic Review" @default.
- W2089430956 cites W1532118541 @default.
- W2089430956 cites W1538393523 @default.
- W2089430956 cites W164398391 @default.
- W2089430956 cites W1690786713 @default.
- W2089430956 cites W1700419946 @default.
- W2089430956 cites W1963799425 @default.
- W2089430956 cites W1966120864 @default.
- W2089430956 cites W1966302727 @default.
- W2089430956 cites W1966923500 @default.
- W2089430956 cites W1967140449 @default.
- W2089430956 cites W1967544980 @default.
- W2089430956 cites W1970987419 @default.
- W2089430956 cites W1971174109 @default.
- W2089430956 cites W1973067272 @default.
- W2089430956 cites W1982755618 @default.
- W2089430956 cites W1985397068 @default.
- W2089430956 cites W1986595501 @default.
- W2089430956 cites W1987288312 @default.
- W2089430956 cites W1988543419 @default.
- W2089430956 cites W1988622196 @default.
- W2089430956 cites W1988821487 @default.
- W2089430956 cites W1991446780 @default.
- W2089430956 cites W1999927824 @default.
- W2089430956 cites W2000369888 @default.
- W2089430956 cites W2000588164 @default.
- W2089430956 cites W2001561891 @default.
- W2089430956 cites W2004459620 @default.
- W2089430956 cites W2005470964 @default.
- W2089430956 cites W2005686769 @default.
- W2089430956 cites W2007036782 @default.
- W2089430956 cites W2011961608 @default.
- W2089430956 cites W2017100113 @default.
- W2089430956 cites W2017638907 @default.
- W2089430956 cites W2018869849 @default.
- W2089430956 cites W2020053051 @default.
- W2089430956 cites W2020580424 @default.
- W2089430956 cites W2021374356 @default.
- W2089430956 cites W2021986426 @default.
- W2089430956 cites W2022044245 @default.
- W2089430956 cites W2025143098 @default.
- W2089430956 cites W2027507811 @default.
- W2089430956 cites W2030746858 @default.
- W2089430956 cites W2031062634 @default.
- W2089430956 cites W2033568227 @default.
- W2089430956 cites W2033686623 @default.
- W2089430956 cites W2036412050 @default.
- W2089430956 cites W2039948014 @default.
- W2089430956 cites W2041628356 @default.
- W2089430956 cites W2041769968 @default.
- W2089430956 cites W2046555967 @default.
- W2089430956 cites W2047997540 @default.
- W2089430956 cites W2048737732 @default.
- W2089430956 cites W2051114553 @default.
- W2089430956 cites W2051556928 @default.
- W2089430956 cites W2053771920 @default.
- W2089430956 cites W2055421336 @default.
- W2089430956 cites W2058417962 @default.
- W2089430956 cites W2058642058 @default.
- W2089430956 cites W2062289126 @default.
- W2089430956 cites W2066259338 @default.
- W2089430956 cites W2066434686 @default.
- W2089430956 cites W2068590125 @default.
- W2089430956 cites W2068665095 @default.
- W2089430956 cites W2069873782 @default.
- W2089430956 cites W2070176794 @default.
- W2089430956 cites W2070685370 @default.
- W2089430956 cites W2071308267 @default.
- W2089430956 cites W2072698640 @default.
- W2089430956 cites W2074184335 @default.
- W2089430956 cites W2075190419 @default.
- W2089430956 cites W2076151007 @default.
- W2089430956 cites W2087092428 @default.
- W2089430956 cites W2087563256 @default.
- W2089430956 cites W2090894469 @default.
- W2089430956 cites W2091046582 @default.
- W2089430956 cites W2098102950 @default.
- W2089430956 cites W2099946862 @default.
- W2089430956 cites W2100443415 @default.
- W2089430956 cites W2100638148 @default.
- W2089430956 cites W2104261859 @default.
- W2089430956 cites W2104899280 @default.