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- W2089473480 endingPage "4571" @default.
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- W2089473480 abstract "The biological evaluation of new Ru(II) complexes carrying dmoPTA (dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) ligands is reported. The results on the biological activity revealed that the organometallic complexes are active against all cell lines with GI50 values in the range 1.1–2.6 μM. When compared to the standard anticancer drug cisplatin, the bimetallic Ru(II) complexes showed a greater activity profile. The cell cycle analysis revealed that the new compounds induced arrest in G1 phase. Contrary to cisplatin, these Ru(II) complexes do not interact with DNA. This result suggests that DNA might not be the key pharmacological target." @default.
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- W2089473480 date "2011-08-01" @default.
- W2089473480 modified "2023-10-18" @default.
- W2089473480 title "Antiproliferative activity of dmoPTA–Ru(II) complexes against human solid tumor cells" @default.
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- W2089473480 doi "https://doi.org/10.1016/j.bmcl.2011.05.116" @default.
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