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- W2089495131 abstract "Cataract remains the major cause of blindness worldwide and a common complication of diabetes. Polyol accumulation in the lens is associated with cataract formation. Here we present evidence for a novel pathway for xylitol production in the lens involving glucuronate metabolism. Xylitol can be produced in rat and bovine lens from glucose, via the enzymes myo-inositol-oxygen oxidoreductase, D-glucuronate reductase, L-gulonate NAD(+)-3-oxidoreductase and L-iditol-NAD(+)-5-oxidoreductase, which have been found in the mammalian lens for the first time. Glucuronate reductase has been purified and was inhibited by thiol quenching reagents. UDP-glucuronyl transferase is also present in mammalian lenses; this enzyme may be an anti-toxic defense mechanism in the lens." @default.
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- W2089495131 date "1996-10-21" @default.
- W2089495131 modified "2023-09-26" @default.
- W2089495131 title "Accumulation of xylitol in the mammalian lens is related to glucuronate metabolism" @default.
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- W2089495131 doi "https://doi.org/10.1016/0014-5793(96)01012-5" @default.
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