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- W2089540857 abstract "A first-order kinetic equation was used to describe the deagglomeration of agglomerates of microfine furosemide particles, ranging in size from 250 μm to 1000 μm, when mixed with mono-dispersed sodium chloride particles with a mean size of 325 μm in either a V-blender or Turbula mixer rotated at different speeds. An increase in mixing time caused an initial rapid decrease in agglomerate size but eventually agglomerate breakdown acquired a self-preserving form. For example, the rate constant decreased from k = 0.358 min−1 to k = 0.034 min−1 when mixtures containing agglomerates with a mean size of 250 μm was mixed in a Turbula mixer at 90 rpm. This suggested that during an initial fast, random mixing process, agglomerates were broken down into single particles and smaller agglomerates by a ball mill effect produced by the sodium chloride particles. During this process smaller agglomerates, mean size below 28 μm, adhered to the sodium chloride particles to produce an ordered mixture. Single particles and even smaller agglomerates were removed from these agglomerates by a combination of abrasion and a process of erosion caused by the mixing process. The relative dominance of the two breakdown mechanisms, and the overall rate and intensity of the total breakdown process, depended on the type of mixer and mixer speed used, and the initial size of the agglomerates." @default.
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- W2089540857 date "1997-05-01" @default.
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- W2089540857 title "Description of the kinetics of the deagglomeration of drug particle agglomerates during powder mixing" @default.
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- W2089540857 doi "https://doi.org/10.1016/s0378-5173(97)04893-x" @default.
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