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- W2089593404 abstract "Naïve CD4(+) T cells are educated in the thymus to survey the periphery for cognate antigen while ignoring self or commensal antigens. T cell antigen receptor (TCR) cross-linking initiates signaling cascades that integrate information from co-stimulatory receptors and locally available cytokines to chart the course of inflammation. The dynamic composition of transcription factors acting within a given T cell drive clonal expansion and specify differentiation into a growing array of effector and regulatory T cell subsets. The classical gamma-interferon (IFNgamma)-secreting T helper type (Th)-1 and IL-4-producing Th2 cell subsets utilize T-bet or GATA3 as master lineage regulators. It is now understood that naïve T cells also differentiate into pro-inflammatory Th17 or tissue-protective inducible T regulatory (iTreg) cells under the respective guidance of RORgammat or FOXP3. Emerging data highlight the reoccurring theme that these Th17 and iTreg master regulators prescribe T cell lineage commitment through interactions with each other, as well as with a broader network of auxiliary transcription factors." @default.
- W2089593404 created "2016-06-24" @default.
- W2089593404 creator A5025258606 @default.
- W2089593404 creator A5046808055 @default.
- W2089593404 date "2010-06-01" @default.
- W2089593404 modified "2023-10-01" @default.
- W2089593404 title "Synergistic and combinatorial control of T cell activation and differentiation by transcription factors" @default.
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- W2089593404 doi "https://doi.org/10.1016/j.coi.2010.03.006" @default.
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