Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089593668> ?p ?o ?g. }
- W2089593668 endingPage "159" @default.
- W2089593668 startingPage "154" @default.
- W2089593668 abstract "Dendritic cell (DC)-based tumor vaccine is a promising therapy for malignancies. Recent studies showed greater potency with DC/tumor fusion vaccines against acute myeloid leukemia and melanoma compared with lysate-pulsed DC vaccines. We compared these two vaccine strategies against murine colon cancer and investigated whether DC/tumor fusion cells continue to produce tumor antigens following fusion as a possible explanation for their increased potency. Using a mouse colon cancer model, CT26, we first showed that the DC/CT26 fusion vaccine is more effective in preventing tumor implantation than CT26 lysate-pulsed DC vaccine. Next, CT26 made to constitutively produce bioactive TGF-beta, a surrogate of tumor-derived products, was fused to DCs and found to produce bioactive TGF-beta 72 h after fusion. Our results suggest the DC/tumor fusion vaccine is more potent against colon cancer than the lysate-pulsed DC vaccine. These fusion cells have the distinct advantage of prolonged interaction with tumor antigens in vivo." @default.
- W2089593668 created "2016-06-24" @default.
- W2089593668 creator A5003693281 @default.
- W2089593668 creator A5026227164 @default.
- W2089593668 creator A5053204257 @default.
- W2089593668 creator A5084599423 @default.
- W2089593668 date "2005-11-01" @default.
- W2089593668 modified "2023-09-23" @default.
- W2089593668 title "Superior efficacy of dendritic cell-tumor fusion vaccine compared with tumor lysate-pulsed dendritic cell vaccine in colon cancer" @default.
- W2089593668 cites W1486555624 @default.
- W2089593668 cites W1541149498 @default.
- W2089593668 cites W1769686661 @default.
- W2089593668 cites W1964037647 @default.
- W2089593668 cites W1964416857 @default.
- W2089593668 cites W1976132628 @default.
- W2089593668 cites W2001258296 @default.
- W2089593668 cites W2024914696 @default.
- W2089593668 cites W2030577394 @default.
- W2089593668 cites W2037988139 @default.
- W2089593668 cites W2045799644 @default.
- W2089593668 cites W2047002794 @default.
- W2089593668 cites W2051699393 @default.
- W2089593668 cites W2057189109 @default.
- W2089593668 cites W2066964346 @default.
- W2089593668 cites W2074229115 @default.
- W2089593668 cites W2075012280 @default.
- W2089593668 cites W2086704878 @default.
- W2089593668 cites W2099186598 @default.
- W2089593668 cites W2106081822 @default.
- W2089593668 cites W2106859466 @default.
- W2089593668 cites W2106934028 @default.
- W2089593668 cites W2124034595 @default.
- W2089593668 doi "https://doi.org/10.1016/j.imlet.2005.05.006" @default.
- W2089593668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15993950" @default.
- W2089593668 hasPublicationYear "2005" @default.
- W2089593668 type Work @default.
- W2089593668 sameAs 2089593668 @default.
- W2089593668 citedByCount "35" @default.
- W2089593668 countsByYear W20895936682012 @default.
- W2089593668 countsByYear W20895936682013 @default.
- W2089593668 countsByYear W20895936682014 @default.
- W2089593668 countsByYear W20895936682016 @default.
- W2089593668 countsByYear W20895936682017 @default.
- W2089593668 countsByYear W20895936682023 @default.
- W2089593668 crossrefType "journal-article" @default.
- W2089593668 hasAuthorship W2089593668A5003693281 @default.
- W2089593668 hasAuthorship W2089593668A5026227164 @default.
- W2089593668 hasAuthorship W2089593668A5053204257 @default.
- W2089593668 hasAuthorship W2089593668A5084599423 @default.
- W2089593668 hasConcept C121608353 @default.
- W2089593668 hasConcept C126322002 @default.
- W2089593668 hasConcept C147483822 @default.
- W2089593668 hasConcept C202751555 @default.
- W2089593668 hasConcept C203014093 @default.
- W2089593668 hasConcept C2777701055 @default.
- W2089593668 hasConcept C2778170410 @default.
- W2089593668 hasConcept C2778378633 @default.
- W2089593668 hasConcept C2780674031 @default.
- W2089593668 hasConcept C502942594 @default.
- W2089593668 hasConcept C55493867 @default.
- W2089593668 hasConcept C57992300 @default.
- W2089593668 hasConcept C71924100 @default.
- W2089593668 hasConcept C86803240 @default.
- W2089593668 hasConcept C8891405 @default.
- W2089593668 hasConceptScore W2089593668C121608353 @default.
- W2089593668 hasConceptScore W2089593668C126322002 @default.
- W2089593668 hasConceptScore W2089593668C147483822 @default.
- W2089593668 hasConceptScore W2089593668C202751555 @default.
- W2089593668 hasConceptScore W2089593668C203014093 @default.
- W2089593668 hasConceptScore W2089593668C2777701055 @default.
- W2089593668 hasConceptScore W2089593668C2778170410 @default.
- W2089593668 hasConceptScore W2089593668C2778378633 @default.
- W2089593668 hasConceptScore W2089593668C2780674031 @default.
- W2089593668 hasConceptScore W2089593668C502942594 @default.
- W2089593668 hasConceptScore W2089593668C55493867 @default.
- W2089593668 hasConceptScore W2089593668C57992300 @default.
- W2089593668 hasConceptScore W2089593668C71924100 @default.
- W2089593668 hasConceptScore W2089593668C86803240 @default.
- W2089593668 hasConceptScore W2089593668C8891405 @default.
- W2089593668 hasIssue "2" @default.
- W2089593668 hasLocation W20895936681 @default.
- W2089593668 hasLocation W20895936682 @default.
- W2089593668 hasOpenAccess W2089593668 @default.
- W2089593668 hasPrimaryLocation W20895936681 @default.
- W2089593668 hasRelatedWork W125978306 @default.
- W2089593668 hasRelatedWork W1973858751 @default.
- W2089593668 hasRelatedWork W2089224354 @default.
- W2089593668 hasRelatedWork W2120938239 @default.
- W2089593668 hasRelatedWork W2346588704 @default.
- W2089593668 hasRelatedWork W2418761422 @default.
- W2089593668 hasRelatedWork W2495094793 @default.
- W2089593668 hasRelatedWork W3105970160 @default.
- W2089593668 hasRelatedWork W3214775378 @default.
- W2089593668 hasRelatedWork W4310278132 @default.
- W2089593668 hasVolume "101" @default.
- W2089593668 isParatext "false" @default.
- W2089593668 isRetracted "false" @default.
- W2089593668 magId "2089593668" @default.