FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089603965> ?p ?o ?g. }

• W2089603965 endingPage "1307" @default.
• W2089603965 startingPage "1300" @default.
• W2089603965 abstract "Adenomatous areas are found frequently within or in the vicinity of carcinoma of the ampulla of Vater. This makes definite diagnosis difficult in the preoperative examination. The adenoma-carcinoma development hypothesis is generally accepted for colorectal tumors. Recently, a genetic alteration model during colorectal tumor development has attracted much attention, leading to various studies. We studied clinicopathologic features, prognostic factors, and the alteration of the p53 tumor suppressor gene using p53 immunohistochemical staining in pure adenomas, pure carcinomas, and carcinomas with adenomatous areas. A proliferative activity of the tumors using Ki-67 was also evaluated. Nine cases of pure adenoma and 198 cases of carcinoma of the ampulla of Vater were selected for this study. Among the 198 cases of thecarcinoma, 83 cases (42%) had adenomatous areas. Positivity of p53 immunohistochemical staining was 0% in pure adenomas, 36% in the adenomatous areas of carcinomas with adenomatous areas and 62% in the carcinomatous areas of carcinomas with adenomatous areas, and 56% in pure carcinoma. Accumulation of p53 protein and the Ki-67 labeling index revealed no significant difference in prognosis. The clinicopathological factors examined were as follows: degree of invasion of the surrounding tissue, such as duodenal wall; pancreatic parenchyma; the presence or absence of lymphatic permeation; venous invasion; perineural invasion; the presence of regional lymph node metastasis; and TNM stage. Each of the clinicopathological factors showed a significant difference. Multivariate analysis revealed strong predictors for a worse prognosis: presence of lymphatic permeation, invasion of the pancreas, and perineural invasion. In conclusion, our results are consistent with the adenoma--carcinoma development hypothesis. It would seem that the molecular events leading to p53 accumulation in neoplasms of the ampulla of Vater occur relatively late during the oncogenetic process. Moreover, we think it may be useful to refer to the p53 overexpression in the diagnosis of ampullary tumors." @default.
• W2089603965 created "2016-06-24" @default.
• W2089603965 creator A5003625644 @default.
• W2089603965 creator A5010476683 @default.
• W2089603965 creator A5025082835 @default.
• W2089603965 creator A5028493586 @default.
• W2089603965 creator A5070478862 @default.
• W2089603965 creator A5078409741 @default.
• W2089603965 creator A5080080439 @default.
• W2089603965 date "2000-12-01" @default.
• W2089603965 modified "2023-10-15" @default.
• W2089603965 title "Carcinoma of the Ampulla of Vater Associated With or Without Adenoma: A Clinicopathologic Analysis of 198 Cases With Reference to p53 and Ki-67 Immunohistochemical Expressions" @default.
• W2089603965 cites W1502822345 @default.
• W2089603965 cites W1995328481 @default.
• W2089603965 cites W2000353345 @default.
• W2089603965 cites W2001258296 @default.
• W2089603965 cites W2021403073 @default.
• W2089603965 cites W2027685974 @default.
• W2089603965 cites W2038522921 @default.
• W2089603965 cites W2041185040 @default.
• W2089603965 cites W2047173879 @default.
• W2089603965 cites W2054020108 @default.
• W2089603965 cites W2055998812 @default.
• W2089603965 cites W2057612022 @default.
• W2089603965 cites W2086776532 @default.
• W2089603965 cites W2091723114 @default.
• W2089603965 cites W2093707146 @default.
• W2089603965 cites W2153589981 @default.
• W2089603965 cites W2170824011 @default.
• W2089603965 cites W2246496424 @default.
• W2089603965 cites W4254654077 @default.
• W2089603965 doi "https://doi.org/10.1038/modpathol.3880238" @default.
• W2089603965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11144926" @default.
• W2089603965 hasPublicationYear "2000" @default.
• W2089603965 type Work @default.
• W2089603965 sameAs 2089603965 @default.
• W2089603965 citedByCount "72" @default.
• W2089603965 countsByYear W20896039652012 @default.
• W2089603965 countsByYear W20896039652013 @default.
• W2089603965 countsByYear W20896039652014 @default.
• W2089603965 countsByYear W20896039652015 @default.
• W2089603965 countsByYear W20896039652016 @default.
• W2089603965 countsByYear W20896039652017 @default.
• W2089603965 countsByYear W20896039652018 @default.
• W2089603965 countsByYear W20896039652019 @default.
• W2089603965 countsByYear W20896039652020 @default.
• W2089603965 countsByYear W20896039652021 @default.
• W2089603965 countsByYear W20896039652022 @default.
• W2089603965 countsByYear W20896039652023 @default.
• W2089603965 crossrefType "journal-article" @default.
• W2089603965 hasAuthorship W2089603965A5003625644 @default.
• W2089603965 hasAuthorship W2089603965A5010476683 @default.
• W2089603965 hasAuthorship W2089603965A5025082835 @default.
• W2089603965 hasAuthorship W2089603965A5028493586 @default.
• W2089603965 hasAuthorship W2089603965A5070478862 @default.
• W2089603965 hasAuthorship W2089603965A5078409741 @default.
• W2089603965 hasAuthorship W2089603965A5080080439 @default.
• W2089603965 hasBestOaLocation W20896039651 @default.
• W2089603965 hasConcept C121608353 @default.
• W2089603965 hasConcept C126322002 @default.
• W2089603965 hasConcept C142724271 @default.
• W2089603965 hasConcept C204232928 @default.
• W2089603965 hasConcept C2777154038 @default.
• W2089603965 hasConcept C2777428134 @default.
• W2089603965 hasConcept C2777546739 @default.
• W2089603965 hasConcept C2778740770 @default.
• W2089603965 hasConcept C2779013556 @default.
• W2089603965 hasConcept C2780840399 @default.
• W2089603965 hasConcept C71924100 @default.
• W2089603965 hasConceptScore W2089603965C121608353 @default.
• W2089603965 hasConceptScore W2089603965C126322002 @default.
• W2089603965 hasConceptScore W2089603965C142724271 @default.
• W2089603965 hasConceptScore W2089603965C204232928 @default.
• W2089603965 hasConceptScore W2089603965C2777154038 @default.
• W2089603965 hasConceptScore W2089603965C2777428134 @default.
• W2089603965 hasConceptScore W2089603965C2777546739 @default.
• W2089603965 hasConceptScore W2089603965C2778740770 @default.
• W2089603965 hasConceptScore W2089603965C2779013556 @default.
• W2089603965 hasConceptScore W2089603965C2780840399 @default.
• W2089603965 hasConceptScore W2089603965C71924100 @default.
• W2089603965 hasIssue "12" @default.
• W2089603965 hasLocation W20896039651 @default.
• W2089603965 hasLocation W20896039652 @default.
• W2089603965 hasOpenAccess W2089603965 @default.
• W2089603965 hasPrimaryLocation W20896039651 @default.
• W2089603965 hasRelatedWork W1932924519 @default.
• W2089603965 hasRelatedWork W2909222828 @default.
• W2089603965 hasRelatedWork W2912546405 @default.
• W2089603965 hasRelatedWork W4210710644 @default.
• W2089603965 hasRelatedWork W4220685019 @default.
• W2089603965 hasRelatedWork W4226108545 @default.
• W2089603965 hasRelatedWork W4250947991 @default.
• W2089603965 hasRelatedWork W4283160439 @default.
• W2089603965 hasRelatedWork W4323531767 @default.
• W2089603965 hasRelatedWork W4385477401 @default.
• W2089603965 hasVolume "13" @default.
• W2089603965 isParatext "false" @default.
• W2089603965 isRetracted "false" @default.

• next