Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089616004> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2089616004 endingPage "321" @default.
- W2089616004 startingPage "315" @default.
- W2089616004 abstract "The effect of ten flavonoids was studied on the stimulation of washed human platelets by either arachidonic acid or thrombin. The oxygenated metabolites released were analyzed by radioimmunoassay, glass-capillary-column gas chromatography and high-pressure liquid chromatography. No effect was evidenced for naringenin, rutinose and phloridzin up to 1000 microM. Thromboxane B2 and 12-hydroxyeicosatetraenoic acid production was depressed simultaneously by all other compounds at different IC50. When tested for their effect on reversibility, however, cyclooxygenase and lipoxygenase inhibition was found to be different depending upon the flavonoid used. All compounds, except morin and rutin, inhibited platelet aggregation and [14C]serotonin release with parallel inhibition of thromboxane synthesis when tested on arachidonic acid-induced platelet-rich plasma stimulation. Some flavonoids inhibited the metabolism of human neutrophils stimulated by ionophore A23187 as assessed by high-performance liquid chromatography. Our results show that flavonoids interfere with the different oxidative metabolisms of arachidonic acid. No clearcut specificity could be found between one compound and one metabolic pathway." @default.
- W2089616004 created "2016-06-24" @default.
- W2089616004 creator A5083308753 @default.
- W2089616004 creator A5088588580 @default.
- W2089616004 date "1985-07-01" @default.
- W2089616004 modified "2023-09-25" @default.
- W2089616004 title "Interference of some flavonoids and non-steroidal anti-inflammatory drugs with oxidative metabolism of arachidonic acid by human platelets and neutrophils" @default.
- W2089616004 cites W1967781822 @default.
- W2089616004 cites W1968998478 @default.
- W2089616004 cites W1982029871 @default.
- W2089616004 cites W2008574207 @default.
- W2089616004 cites W2008770403 @default.
- W2089616004 cites W2056343330 @default.
- W2089616004 cites W2065395270 @default.
- W2089616004 cites W2072396233 @default.
- W2089616004 cites W2074459205 @default.
- W2089616004 cites W2075049013 @default.
- W2089616004 cites W2076920305 @default.
- W2089616004 cites W2151536432 @default.
- W2089616004 cites W2164931507 @default.
- W2089616004 cites W2741219303 @default.
- W2089616004 cites W4244832660 @default.
- W2089616004 doi "https://doi.org/10.1016/0005-2760(85)90287-5" @default.
- W2089616004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3924112" @default.
- W2089616004 hasPublicationYear "1985" @default.
- W2089616004 type Work @default.
- W2089616004 sameAs 2089616004 @default.
- W2089616004 citedByCount "85" @default.
- W2089616004 countsByYear W20896160042012 @default.
- W2089616004 countsByYear W20896160042013 @default.
- W2089616004 countsByYear W20896160042014 @default.
- W2089616004 countsByYear W20896160042015 @default.
- W2089616004 countsByYear W20896160042016 @default.
- W2089616004 countsByYear W20896160042017 @default.
- W2089616004 countsByYear W20896160042021 @default.
- W2089616004 countsByYear W20896160042022 @default.
- W2089616004 crossrefType "journal-article" @default.
- W2089616004 hasAuthorship W2089616004A5083308753 @default.
- W2089616004 hasAuthorship W2089616004A5088588580 @default.
- W2089616004 hasConcept C126322002 @default.
- W2089616004 hasConcept C181199279 @default.
- W2089616004 hasConcept C185592680 @default.
- W2089616004 hasConcept C2776785769 @default.
- W2089616004 hasConcept C2776848411 @default.
- W2089616004 hasConcept C2778004101 @default.
- W2089616004 hasConcept C2778078955 @default.
- W2089616004 hasConcept C2779054382 @default.
- W2089616004 hasConcept C2779689624 @default.
- W2089616004 hasConcept C2780857362 @default.
- W2089616004 hasConcept C2781080829 @default.
- W2089616004 hasConcept C43617362 @default.
- W2089616004 hasConcept C55493867 @default.
- W2089616004 hasConcept C71924100 @default.
- W2089616004 hasConcept C89560881 @default.
- W2089616004 hasConceptScore W2089616004C126322002 @default.
- W2089616004 hasConceptScore W2089616004C181199279 @default.
- W2089616004 hasConceptScore W2089616004C185592680 @default.
- W2089616004 hasConceptScore W2089616004C2776785769 @default.
- W2089616004 hasConceptScore W2089616004C2776848411 @default.
- W2089616004 hasConceptScore W2089616004C2778004101 @default.
- W2089616004 hasConceptScore W2089616004C2778078955 @default.
- W2089616004 hasConceptScore W2089616004C2779054382 @default.
- W2089616004 hasConceptScore W2089616004C2779689624 @default.
- W2089616004 hasConceptScore W2089616004C2780857362 @default.
- W2089616004 hasConceptScore W2089616004C2781080829 @default.
- W2089616004 hasConceptScore W2089616004C43617362 @default.
- W2089616004 hasConceptScore W2089616004C55493867 @default.
- W2089616004 hasConceptScore W2089616004C71924100 @default.
- W2089616004 hasConceptScore W2089616004C89560881 @default.
- W2089616004 hasIssue "2" @default.
- W2089616004 hasLocation W20896160041 @default.
- W2089616004 hasLocation W20896160042 @default.
- W2089616004 hasOpenAccess W2089616004 @default.
- W2089616004 hasPrimaryLocation W20896160041 @default.
- W2089616004 hasRelatedWork W1537643674 @default.
- W2089616004 hasRelatedWork W1968942653 @default.
- W2089616004 hasRelatedWork W1981662210 @default.
- W2089616004 hasRelatedWork W2026574739 @default.
- W2089616004 hasRelatedWork W2030268316 @default.
- W2089616004 hasRelatedWork W2076598828 @default.
- W2089616004 hasRelatedWork W2086854264 @default.
- W2089616004 hasRelatedWork W2320757263 @default.
- W2089616004 hasRelatedWork W2412214359 @default.
- W2089616004 hasRelatedWork W2884644605 @default.
- W2089616004 hasVolume "835" @default.
- W2089616004 isParatext "false" @default.
- W2089616004 isRetracted "false" @default.
- W2089616004 magId "2089616004" @default.
- W2089616004 workType "article" @default.