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- W2089623763 abstract "The biological effects of the p53 tumor suppressor protein are elicited, at least in part, through sequence-specific transactivation of a battery of target genes. The differential display method was employed towards identifying additional p53 target genes, with emphasis on genes whose induction may contribute to p53-mediated apoptosis. We report here the cloning of a novel p53-inducible gene, designated PAG608. PAG608 transcripts are induced by DNA damage in a p53-dependent manner. PAG608 encodes a nuclear zinc finger protein, which appears to localize preferentially to nucleoli when expressed at moderate levels in transfected cells. Transient overexpression of PAG608 in human tumor-derived cells leads to distinctive changes in nuclear morphology, and can promote apoptosis. Together with additional p53 target genes, PAG608 may therefore play a role in mediating the biological activities of p53." @default.
- W2089623763 created "2016-06-24" @default.
- W2089623763 creator A5048676585 @default.
- W2089623763 date "1997-07-15" @default.
- W2089623763 modified "2023-10-18" @default.
- W2089623763 title "A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis" @default.
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- W2089623763 doi "https://doi.org/10.1093/emboj/16.14.4384" @default.
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