FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089629762> ?p ?o ?g. }

• W2089629762 endingPage "356" @default.
• W2089629762 startingPage "346" @default.
• W2089629762 abstract "The effect of media supplements on total and polyglutamylfolate concentrations has been examined in Neurospora crassa wild type (FGSC 853), an ethionine-resistant mutant (FGSC 1212), and a methionine auxotroph (FGSC 1330) which lacks folylpolyglutamate synthetase. When the culture medium contained 1 mm glycine, folate concentrations in the wild type were increased by over 90% and more p-[3H]aminobenzoate was incorporated into folates. Growth in l-methionine-supplemented media (1–5 mm) decreased folate levels and labeling in all three strains. In the wild type, this effect of l-methionine was reversed on transfer to unsupplemented media but p-[3H]aminobenzoate pulse-chase experiments suggested that exogenous methionine did not increase the turnover of labeled folates. At 1 mm, d-methionine did not affect polyglutamylfolate labeling but l-methionine reduced 3H incorporation by 65% in the wild type. Ion-exchange chromatography showed that p-[3H]aminobenzoate was incorporated in formyl- and methyltetrahydrofolates which in the wild type, were principally hexaglutamyl derivatives. Glycine-supplemented growth yielded labeled folates that were 24% heptaglutamates but these and pentaglutamates were lacking when l-methionine was supplied. The specific activity of GTP cyclohydrolase was not significantly affected by culture in l-methionine-containing media. Dialysis and gel filtration both lowered enzyme activities and product formation was not changed when up to 10 μmol of l-methionine was added to the reaction system. The data suggest that methionine or its metabolic products exerts some control over folate production which is distinct from the established inhibition of methylenetetrahydrofolate reductase by AdoMet." @default.
• W2089629762 created "2016-06-24" @default.
• W2089629762 creator A5025546265 @default.
• W2089629762 creator A5044596799 @default.
• W2089629762 date "1980-04-01" @default.
• W2089629762 modified "2023-09-23" @default.
• W2089629762 title "Polyglutamylfolate synthesis in Neurospora crassa: Changes in pool size following growth in glycine- and methionine-supplemented media" @default.
• W2089629762 cites W1483768139 @default.
• W2089629762 cites W1485678634 @default.
• W2089629762 cites W1494057533 @default.
• W2089629762 cites W1503770775 @default.
• W2089629762 cites W1549768447 @default.
• W2089629762 cites W1775749144 @default.
• W2089629762 cites W1963977559 @default.
• W2089629762 cites W1970310258 @default.
• W2089629762 cites W1976650976 @default.
• W2089629762 cites W1980617135 @default.
• W2089629762 cites W1991793766 @default.
• W2089629762 cites W2002663495 @default.
• W2089629762 cites W2006058469 @default.
• W2089629762 cites W2014827282 @default.
• W2089629762 cites W2017886062 @default.
• W2089629762 cites W2020939964 @default.
• W2089629762 cites W2032000461 @default.
• W2089629762 cites W2032341323 @default.
• W2089629762 cites W2035709704 @default.
• W2089629762 cites W2039529655 @default.
• W2089629762 cites W2045714210 @default.
• W2089629762 cites W2050864264 @default.
• W2089629762 cites W2055189653 @default.
• W2089629762 cites W2057521652 @default.
• W2089629762 cites W2058992968 @default.
• W2089629762 cites W2071004763 @default.
• W2089629762 cites W2078393504 @default.
• W2089629762 cites W2088589310 @default.
• W2089629762 cites W2101797966 @default.
• W2089629762 cites W2113449921 @default.
• W2089629762 cites W2125380507 @default.
• W2089629762 cites W2132597572 @default.
• W2089629762 cites W2215943057 @default.
• W2089629762 cites W2228703578 @default.
• W2089629762 cites W2301830913 @default.
• W2089629762 cites W2327013087 @default.
• W2089629762 cites W2337715798 @default.
• W2089629762 cites W2403041455 @default.
• W2089629762 cites W2410223113 @default.
• W2089629762 cites W2412620147 @default.
• W2089629762 cites W2470936232 @default.
• W2089629762 cites W4253219926 @default.
• W2089629762 cites W952775709 @default.
• W2089629762 doi "https://doi.org/10.1016/0003-9861(80)90364-1" @default.
• W2089629762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6449176" @default.
• W2089629762 hasPublicationYear "1980" @default.
• W2089629762 type Work @default.
• W2089629762 sameAs 2089629762 @default.
• W2089629762 citedByCount "20" @default.
• W2089629762 crossrefType "journal-article" @default.
• W2089629762 hasAuthorship W2089629762A5025546265 @default.
• W2089629762 hasAuthorship W2089629762A5044596799 @default.
• W2089629762 hasConcept C104317684 @default.
• W2089629762 hasConcept C143065580 @default.
• W2089629762 hasConcept C181199279 @default.
• W2089629762 hasConcept C185592680 @default.
• W2089629762 hasConcept C2776739539 @default.
• W2089629762 hasConcept C2777756961 @default.
• W2089629762 hasConcept C2780486903 @default.
• W2089629762 hasConcept C2780912031 @default.
• W2089629762 hasConcept C2780919596 @default.
• W2089629762 hasConcept C515207424 @default.
• W2089629762 hasConcept C523546767 @default.
• W2089629762 hasConcept C54355233 @default.
• W2089629762 hasConcept C553450214 @default.
• W2089629762 hasConcept C55493867 @default.
• W2089629762 hasConcept C80315684 @default.
• W2089629762 hasConcept C86803240 @default.
• W2089629762 hasConceptScore W2089629762C104317684 @default.
• W2089629762 hasConceptScore W2089629762C143065580 @default.
• W2089629762 hasConceptScore W2089629762C181199279 @default.
• W2089629762 hasConceptScore W2089629762C185592680 @default.
• W2089629762 hasConceptScore W2089629762C2776739539 @default.
• W2089629762 hasConceptScore W2089629762C2777756961 @default.
• W2089629762 hasConceptScore W2089629762C2780486903 @default.
• W2089629762 hasConceptScore W2089629762C2780912031 @default.
• W2089629762 hasConceptScore W2089629762C2780919596 @default.
• W2089629762 hasConceptScore W2089629762C515207424 @default.
• W2089629762 hasConceptScore W2089629762C523546767 @default.
• W2089629762 hasConceptScore W2089629762C54355233 @default.
• W2089629762 hasConceptScore W2089629762C553450214 @default.
• W2089629762 hasConceptScore W2089629762C55493867 @default.
• W2089629762 hasConceptScore W2089629762C80315684 @default.
• W2089629762 hasConceptScore W2089629762C86803240 @default.
• W2089629762 hasIssue "2" @default.
• W2089629762 hasLocation W20896297621 @default.
• W2089629762 hasLocation W20896297622 @default.
• W2089629762 hasOpenAccess W2089629762 @default.
• W2089629762 hasPrimaryLocation W20896297621 @default.
• W2089629762 hasRelatedWork W111279495 @default.
• W2089629762 hasRelatedWork W1499380138 @default.

• next