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• W2089632007 abstract "The resolution of 1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-benzodiazepin-4-one (+/-)-(R,S)-2 was accomplished by chiral HPLC. The absolute configuration of (+)-2, determined by X-ray crystallographic analysis, was R. The in vivo anticonvulsant activity of the enantiomers (+)-(R)-2 and (-)-(S)-2 is reported. It has been also demonstrated that compound (+/-)-(R,S)-2 in vivo undergoes oxidative metabolism to derivative 1." @default.
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• W2089632007 date "2006-01-01" @default.
• W2089632007 modified "2023-10-16" @default.
• W2089632007 title "Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one" @default.
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• W2089632007 doi "https://doi.org/10.1002/chir.20333" @default.
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