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• W2089633523 abstract "The treatment of posttransplant lymphoproliferative disorder (PTLD) remains empirical. We review our treatment of seven cases of PTLD consisting of five interventions: 1) reduction of immunosuppression; 2) antiviral drugs; 3) interferon-alpha; 4) gamma-globulins; and 5) anti-CD19 monoclonal antibodies. METHODS AND RESULTS; Seven consecutive patients who had undergone a simultaneous pancreas-kidney, liver, heart, or kidney transplantation were treated. One patient acquired a primary EBV infection with an oligoclonal immunoblastic lymphoma early after pancreas-kidney transplantation; all others developed a monoclonal polymorphic or immunoblastic lymphoma 2 to 123 months after transplantation. In all patients extranodal sites were involved, in three the graft was also involved. Five patients received the full quintuple approach and all rapidly obtained a complete remission (CR) with a median follow-up of 31 months (7-74 months). Of the two patients who did not receive interferon-alpha for fear of graft rejection one responded slowly with a CR after 7 months, and the other obtained a rapid CR followed by a relapse at 4 months. All three patients with a liver or heart transplant could keep their graft. All patients are still alive with a median follow-up of 31 months (7-74 months).This combined approach resulted in a favorable outcome in patients with high risk monoclonal PTLD after solid organ transplantation." @default.
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• W2089633523 date "2001-01-01" @default.
• W2089633523 modified "2023-09-30" @default.
• W2089633523 title "SUCCESSFUL OUTCOME WITH A ???QUINTUPLE APPROACH??? OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER" @default.
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• W2089633523 doi "https://doi.org/10.1097/00007890-200101150-00008" @default.
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