Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089635679> ?p ?o ?g. }
- W2089635679 endingPage "10" @default.
- W2089635679 startingPage "1" @default.
- W2089635679 abstract "Neurodegeneration is characterized by progressive loss of structure and function of neurons. Several therapeutic methods and drugs are available to alleviate the symptoms of these diseases. The currently used delivery strategies such as implantation of catheters, intracarotid infusions, surgeries, and chemotherapies are invasive in nature and pose a greater risk of postsurgical complications, which can have fatal side effects. The current study utilizes a peptide (TAT and MGF) tagged PEGylated chitosan nanoparticle formulation for siRNA delivery, administered intranasally, which can bypass the blood brain barrier. The study investigates the optimal dose, duration, biodistribution, and toxicity, of the nanoparticle-siRNA formulation, in-vivo. The results indicate that 0.5 mg/kg of siRNA is delivered successfully to the hippocampus, thalamus, hypothalamus, and Purkinje cells in the cerebellum after 4 hrs of post intranasal delivery. The results indicate maximum delivery to the brain in comparison to other tissues with no cellular toxic effects. This study shows the potential of peptide-tagged PEGylated chitosan nanoparticles to be delivered intranasally and target brain tissue for the treatment of neurological disorders." @default.
- W2089635679 created "2016-06-24" @default.
- W2089635679 creator A5006582787 @default.
- W2089635679 creator A5036032663 @default.
- W2089635679 creator A5039402697 @default.
- W2089635679 creator A5065954072 @default.
- W2089635679 date "2013-09-12" @default.
- W2089635679 modified "2023-09-24" @default.
- W2089635679 title "Intranasal, siRNA Delivery to the Brain by TAT/MGF Tagged PEGylated Chitosan Nanoparticles" @default.
- W2089635679 cites W1485563738 @default.
- W2089635679 cites W1530110845 @default.
- W2089635679 cites W1655307540 @default.
- W2089635679 cites W1671620727 @default.
- W2089635679 cites W1964276428 @default.
- W2089635679 cites W1973397721 @default.
- W2089635679 cites W1974488802 @default.
- W2089635679 cites W1974623341 @default.
- W2089635679 cites W1976936889 @default.
- W2089635679 cites W1977559821 @default.
- W2089635679 cites W1982188484 @default.
- W2089635679 cites W1994362299 @default.
- W2089635679 cites W2002968476 @default.
- W2089635679 cites W2016148953 @default.
- W2089635679 cites W2018340655 @default.
- W2089635679 cites W2021040047 @default.
- W2089635679 cites W2025486324 @default.
- W2089635679 cites W2031892070 @default.
- W2089635679 cites W2032102818 @default.
- W2089635679 cites W2032496099 @default.
- W2089635679 cites W2036794860 @default.
- W2089635679 cites W2040022930 @default.
- W2089635679 cites W2045949951 @default.
- W2089635679 cites W2049799057 @default.
- W2089635679 cites W2049995305 @default.
- W2089635679 cites W2050167321 @default.
- W2089635679 cites W2050582434 @default.
- W2089635679 cites W2062516622 @default.
- W2089635679 cites W2066234893 @default.
- W2089635679 cites W2067658086 @default.
- W2089635679 cites W2068506297 @default.
- W2089635679 cites W2072692763 @default.
- W2089635679 cites W2077756131 @default.
- W2089635679 cites W2078674519 @default.
- W2089635679 cites W2083588057 @default.
- W2089635679 cites W2088849426 @default.
- W2089635679 cites W2098906123 @default.
- W2089635679 cites W2105668301 @default.
- W2089635679 cites W2111303385 @default.
- W2089635679 cites W2113945122 @default.
- W2089635679 cites W2115282717 @default.
- W2089635679 cites W2117998176 @default.
- W2089635679 cites W2119607029 @default.
- W2089635679 cites W2124020258 @default.
- W2089635679 cites W2125541186 @default.
- W2089635679 cites W2125965105 @default.
- W2089635679 cites W2130639482 @default.
- W2089635679 cites W2135062838 @default.
- W2089635679 cites W2138821334 @default.
- W2089635679 cites W2154171978 @default.
- W2089635679 cites W2216897043 @default.
- W2089635679 cites W4230035716 @default.
- W2089635679 doi "https://doi.org/10.1155/2013/812387" @default.
- W2089635679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4590831" @default.
- W2089635679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26555995" @default.
- W2089635679 hasPublicationYear "2013" @default.
- W2089635679 type Work @default.
- W2089635679 sameAs 2089635679 @default.
- W2089635679 citedByCount "19" @default.
- W2089635679 countsByYear W20896356792014 @default.
- W2089635679 countsByYear W20896356792015 @default.
- W2089635679 countsByYear W20896356792016 @default.
- W2089635679 countsByYear W20896356792019 @default.
- W2089635679 countsByYear W20896356792020 @default.
- W2089635679 countsByYear W20896356792021 @default.
- W2089635679 countsByYear W20896356792022 @default.
- W2089635679 countsByYear W20896356792023 @default.
- W2089635679 crossrefType "journal-article" @default.
- W2089635679 hasAuthorship W2089635679A5006582787 @default.
- W2089635679 hasAuthorship W2089635679A5036032663 @default.
- W2089635679 hasAuthorship W2089635679A5039402697 @default.
- W2089635679 hasAuthorship W2089635679A5065954072 @default.
- W2089635679 hasBestOaLocation W20896356791 @default.
- W2089635679 hasConcept C104317684 @default.
- W2089635679 hasConcept C126322002 @default.
- W2089635679 hasConcept C150903083 @default.
- W2089635679 hasConcept C185592680 @default.
- W2089635679 hasConcept C207001950 @default.
- W2089635679 hasConcept C22615655 @default.
- W2089635679 hasConcept C2776925932 @default.
- W2089635679 hasConcept C2777807558 @default.
- W2089635679 hasConcept C2778402981 @default.
- W2089635679 hasConcept C2779134260 @default.
- W2089635679 hasConcept C2779732960 @default.
- W2089635679 hasConcept C29730261 @default.
- W2089635679 hasConcept C529278444 @default.
- W2089635679 hasConcept C54009773 @default.
- W2089635679 hasConcept C55493867 @default.
- W2089635679 hasConcept C71924100 @default.