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• W2089660388 abstract "Knowledge of baculovirus–insect host interactions at a genome-scale level is important for developing a number of baculovirus-based applications, but the gathering of such knowledge is hindered by the lack of genomic sequences in most insect hosts. In this study, expression kinetics of 24,206 Helicoverpa zea insect transcripts and 134 Helicoverpa armigera nucleopolyhedrovirus (HearNPV) genes at 0, 12, 24 and 48 h post-infection (hpi) were simultaneously analyzed using microarrays, which were developed from sequences obtained by deep transcriptome sequencing. Host genes in pathways important for infection such as those for energy generation, anti-viral peptides, apoptosis, detoxification, DNA polymerase activities, RNA polymerase activities, translation initiation, protein processing and cell cycle arrest were identified. Differential expression was linked to changes in the number of intracellular and extracellular viral genomes and occlusion bodies. The first comprehensive elucidation of HearNPV–H. zea expression kinetics was obtained." @default.
• W2089660388 created "2016-06-24" @default.
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• W2089660388 date "2013-09-01" @default.
• W2089660388 modified "2023-09-27" @default.
• W2089660388 title "Genome scale analysis of differential mRNA expression of Helicoverpa zea insect cells infected with a H. armigera baculovirus" @default.
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• W2089660388 doi "https://doi.org/10.1016/j.virol.2013.06.004" @default.
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