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- W2089668087 abstract "The tumor stroma, consisting of non-malignant cells and the extracellular matrix, undergoes significant quantitative and qualitative changes throughout malignant transformation and tumor progression. With increasing recognition of the role of the tumor microenvironment in disease progression, stromal components of the tumor have become attractive targets for therapeutic intervention. Stromal accumulation of the glycosaminoglycan hyaluronan occurs in many tumor types and is frequently associated with a negative disease prognosis. Hyaluronan interacts with other extracellular molecules as well as cellular receptors to form a complex interaction network influencing physicochemical properties, signal transduction, and biological behavior of cancer cells. In preclinical animal models, enzymatic removal of hyaluronan is associated with remodeling of the tumor stroma, reduction of tumor interstitial fluid pressure, expansion of tumor blood vessels and facilitated delivery of chemotherapy. This leads to inhibition of tumor growth and increased survival. Current evidence shows that abnormal accumulation of hyaluronan may be an important stromal target for cancer therapy. In this review we highlight the role of hyaluronan and hyaluronan-mediated interactions in cancer, and discuss historical and recent data on hyaluronidase-based therapies and the effect of hyaluronan removal on tumor growth." @default.
- W2089668087 created "2016-06-24" @default.
- W2089668087 creator A5023977680 @default.
- W2089668087 creator A5028580343 @default.
- W2089668087 creator A5028896261 @default.
- W2089668087 creator A5031319377 @default.
- W2089668087 creator A5068765890 @default.
- W2089668087 creator A5084461414 @default.
- W2089668087 date "2012-09-06" @default.
- W2089668087 modified "2023-10-16" @default.
- W2089668087 title "Therapeutic Targeting of Hyaluronan in the Tumor Stroma" @default.
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