FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089678021> ?p ?o ?g. }

• W2089678021 endingPage "2484" @default.
• W2089678021 startingPage "2477" @default.
• W2089678021 abstract "In Brief Study Design. The possibility to prevent nucleus pulposus-induced structural changes of the dorsal root ganglion (DRG) by selective tumor necrosis factor-α (TNF-α) inhibition was assessed in an experimental model in the rat spine. Objectives. To evaluate the role of TNF-α in the mediation of nucleus pulposus-induced structural changes by using selective inhibition and to confirm the effect of TNF-α inhibitor at the point of histologic findings. Summary of Background Data. TNF-α is known to be released from the nucleus pulposus, and has been suggested to play a key role in chemical damage of the adjacent nerve tissue. The TNF-α inhibitor prevents the reduction of nerve conduction velocity and may limit the nerve fiber injury, intracapillary thrombus formation, and intraneural edema formation caused by nucleus pulposus. However, there is no report on the effect of the inhibitor regarding histologic findings and the appearance of the TNF-α in the DRG exposed to nucleus pulposus. Methods. 1) Rats were treated with an intraperitoneal injection of infliximab. Nucleus pulposus from the disc was obtained 1, 3, 7, 14, and 21 days after the injection. The TNF-α-positive cells were observed using immunohistochemistry. 2) Disc herniation of the nucleus pulposus was made on the L4–L5 disc in rats. Two groups were treated with selective TNF-α inhibitor 1 day before or 3 hours after surgery. The other group received no TNF-α inhibitor. The L4 DRG was resected 1, 3, 7, 14, and 21 days after surgery. The specimens were processed for hematoxylin and eosin staining and immunohistochemistry using rabbit antisera to TNF-α. The histologic findings and TNF-α-positive cells were observed by light microscopy. Results. 1) While positively stained immunoreactive TNF-α appeared between 7 and 21 days, no immunoreactive TNF-α was observed 1 and 3 days after injection in the nucleus pulposus. 2) The histologic changes of the DRG caused by nucleus pulposus were smaller in the infliximab treatment group than those in the nontreatment group. The number of immunoreactive TNF-α cells was high 1 and 3 days after surgery in the DRGs of disc herniation rats that were treated without an injection of the inhibitor, low on day 7 and 14, and very low on day 21 after surgery. No immunoreactive TNF-α was observed in the DRGs of the TNF-α inhibitor treatment groups on day 1, 3, and 21 after surgery. Weakly stained cells were sometimes observed in rats at day 7 and 14 after surgery. Conclusions. Infliximab may prevent the histologic damage induced by nucleus pulposus. When rats were given a single intraperitoneal injection of infliximab at the beginning of disc herniation, the histologic damage seemed to be reduced in comparison with the nontreated rats. We studied the effects of a tumor necrosis factor-α (TNF-α) inhibitor with special reference to distribution of TNF-α and histologic changes in the dorsal root ganglion following experimental disc herniation in rats. The nucleus pulposus-induced deformity on the dorsal root ganglion was prevented by an injection of infliximab in comparison with the nontreatment group." @default.
• W2089678021 created "2016-06-24" @default.
• W2089678021 creator A5019487676 @default.
• W2089678021 creator A5029515495 @default.
• W2089678021 creator A5036381292 @default.
• W2089678021 creator A5049608115 @default.
• W2089678021 creator A5080980467 @default.
• W2089678021 date "2004-11-01" @default.
• W2089678021 modified "2023-10-17" @default.
• W2089678021 title "Selective Inhibition of Tumor Necrosis Factor-α Prevents Nucleus Pulposus-Induced Histologic Changes in the Dorsal Root Ganglion" @default.
• W2089678021 cites W1971685694 @default.
• W2089678021 cites W1981964636 @default.
• W2089678021 cites W1984632338 @default.
• W2089678021 cites W1998273056 @default.
• W2089678021 cites W1999138373 @default.
• W2089678021 cites W2008120138 @default.
• W2089678021 cites W2015457336 @default.
• W2089678021 cites W2016735320 @default.
• W2089678021 cites W2020575544 @default.
• W2089678021 cites W2029227926 @default.
• W2089678021 cites W2030279898 @default.
• W2089678021 cites W2035092856 @default.
• W2089678021 cites W2043959655 @default.
• W2089678021 cites W2044561802 @default.
• W2089678021 cites W2055397848 @default.
• W2089678021 cites W2069346876 @default.
• W2089678021 cites W2072355351 @default.
• W2089678021 cites W2072738451 @default.
• W2089678021 cites W2078799084 @default.
• W2089678021 cites W2085582538 @default.
• W2089678021 cites W2088168363 @default.
• W2089678021 cites W2107359322 @default.
• W2089678021 cites W2153969760 @default.
• W2089678021 cites W2321453230 @default.
• W2089678021 cites W2322118981 @default.
• W2089678021 cites W2324054405 @default.
• W2089678021 cites W2325250392 @default.
• W2089678021 cites W2326222152 @default.
• W2089678021 cites W2331471919 @default.
• W2089678021 cites W2410249905 @default.
• W2089678021 cites W4381157394 @default.
• W2089678021 doi "https://doi.org/10.1097/01.brs.0000144406.17512.ea" @default.
• W2089678021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15543058" @default.
• W2089678021 hasPublicationYear "2004" @default.
• W2089678021 type Work @default.
• W2089678021 sameAs 2089678021 @default.
• W2089678021 citedByCount "53" @default.
• W2089678021 countsByYear W20896780212012 @default.
• W2089678021 countsByYear W20896780212013 @default.
• W2089678021 countsByYear W20896780212014 @default.
• W2089678021 countsByYear W20896780212016 @default.
• W2089678021 countsByYear W20896780212017 @default.
• W2089678021 countsByYear W20896780212019 @default.
• W2089678021 countsByYear W20896780212020 @default.
• W2089678021 countsByYear W20896780212021 @default.
• W2089678021 crossrefType "journal-article" @default.
• W2089678021 hasAuthorship W2089678021A5019487676 @default.
• W2089678021 hasAuthorship W2089678021A5029515495 @default.
• W2089678021 hasAuthorship W2089678021A5036381292 @default.
• W2089678021 hasAuthorship W2089678021A5049608115 @default.
• W2089678021 hasAuthorship W2089678021A5080980467 @default.
• W2089678021 hasConcept C105702510 @default.
• W2089678021 hasConcept C118552586 @default.
• W2089678021 hasConcept C125473707 @default.
• W2089678021 hasConcept C126322002 @default.
• W2089678021 hasConcept C140530291 @default.
• W2089678021 hasConcept C142724271 @default.
• W2089678021 hasConcept C17991360 @default.
• W2089678021 hasConcept C204232928 @default.
• W2089678021 hasConcept C2776281502 @default.
• W2089678021 hasConcept C2780723820 @default.
• W2089678021 hasConcept C2780886150 @default.
• W2089678021 hasConcept C71924100 @default.
• W2089678021 hasConceptScore W2089678021C105702510 @default.
• W2089678021 hasConceptScore W2089678021C118552586 @default.
• W2089678021 hasConceptScore W2089678021C125473707 @default.
• W2089678021 hasConceptScore W2089678021C126322002 @default.
• W2089678021 hasConceptScore W2089678021C140530291 @default.
• W2089678021 hasConceptScore W2089678021C142724271 @default.
• W2089678021 hasConceptScore W2089678021C17991360 @default.
• W2089678021 hasConceptScore W2089678021C204232928 @default.
• W2089678021 hasConceptScore W2089678021C2776281502 @default.
• W2089678021 hasConceptScore W2089678021C2780723820 @default.
• W2089678021 hasConceptScore W2089678021C2780886150 @default.
• W2089678021 hasConceptScore W2089678021C71924100 @default.
• W2089678021 hasIssue "22" @default.
• W2089678021 hasLocation W20896780211 @default.
• W2089678021 hasLocation W20896780212 @default.
• W2089678021 hasOpenAccess W2089678021 @default.
• W2089678021 hasPrimaryLocation W20896780211 @default.
• W2089678021 hasRelatedWork W1234495162 @default.
• W2089678021 hasRelatedWork W2011949887 @default.
• W2089678021 hasRelatedWork W2054352305 @default.
• W2089678021 hasRelatedWork W2079153990 @default.
• W2089678021 hasRelatedWork W2107989442 @default.
• W2089678021 hasRelatedWork W2375803463 @default.
• W2089678021 hasRelatedWork W2381576875 @default.
• W2089678021 hasRelatedWork W2393033873 @default.

• next