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• W2089684513 endingPage "852" @default.
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• W2089684513 abstract "The role of the brain 5-HT1A receptor in cognition was examined in the water maze (WM) and passive avoidance (PA) tasks in the male rat. Pre-training administration of the 5-HT1A receptor agonist 8-OH-DPAT impaired WM performance and facilitated PA retention at low doses (0.01 and 0.03 mg/kg) and impaired PA retention at higher doses (0.1-1.0 mg/kg). The 5-HT1A receptor antagonist NAD-299 produced a dose-dependent facilitation of PA retention. In contrast, the 5-HT1A receptor antagonists NAD-299 and WAY-100635 failed to alter acquisition and retention in the WM. The impairments in WM and PA (but not facilitation in PA) induced by 8-OH-DPAT were blocked by NAD-299. Furthermore, NAD-299 prevented the PA impairments induced by the muscarinic antagonist scopolamine or the NMDA receptor antagonist MK-801. In contrast, NAD-299 and WAY-100635 failed to attenuate the WM impairment induced by scopolamine, probably due to the failure of 5-HT1A receptor blockade to attenuate the sensorimotor disturbances induced by scopolamine. These results indicate that 5-HT1A receptor stimulation and blockade result in opposite effects in two types of cognitive tasks in the rat, and that 5-HT1A receptor blockade can facilitate some aspects of cognitive function, probably via modulation of cholinergic and glutamatergic transmissions. This suggests that 5-HT1A receptor antagonists may have a potential role in the treatment of human degenerative disorders associated with cognitive deficits." @default.
• W2089684513 created "2016-06-24" @default.
• W2089684513 creator A5035523228 @default.
• W2089684513 creator A5041142381 @default.
• W2089684513 creator A5083901887 @default.
• W2089684513 creator A5091613999 @default.
• W2089684513 date "2005-05-01" @default.
• W2089684513 modified "2023-10-03" @default.
• W2089684513 title "Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat" @default.
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• W2089684513 doi "https://doi.org/10.1016/j.neuropharm.2005.01.007" @default.
• W2089684513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15829255" @default.
• W2089684513 hasPublicationYear "2005" @default.
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