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- W2089707160 abstract "Summary Synthalin A (decamethylenediguanidine) is a toxic, hypoglycemic agent which has been reported to cause histological changes in the liver, kidneys, and alpha cells of the Islets of Langerhans, and also to depress hepatic function in dairy bull calves. Five Holstein bull calves (eight days of age) were treated with a single intramuscular injection of synthalin A at the rate of 2.2 mg. per kilogram of body weight. Renal function as measured by both phenolsulfonphthalein fractional and volume clearances was depressed to approximately 35% of normal within 16 hr., and had returned to near-normal values within seven days. Correspondingly, plasma glucose levels decreased from a mean preinjection level of 85.6 mg. % to 32.8 mg. % at 16 hr. after injection, and returned to normal levels again within 66 hr. after injection. These effects were significant statistically (P" @default.
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- W2089707160 date "1959-08-01" @default.
- W2089707160 modified "2023-09-30" @default.
- W2089707160 title "Effect of Synthalin a on Renal Function in Dairy Bull Calves as Measured by Phenolsulfonphthalein Clearance" @default.
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- W2089707160 doi "https://doi.org/10.3168/jds.s0022-0302(59)90746-5" @default.
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