FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089709024> ?p ?o ?g. }

• W2089709024 endingPage "2942" @default.
• W2089709024 startingPage "2935" @default.
• W2089709024 abstract "In an attempt to search for new and alternative antimalarial agents, a series of unsubstituted and 6-trifluoromethyl-1,2,4-triazino[5,6b]indole and 5H-1,2,4-triazolo[1',5',2,3]-1,2,4-triazino[5,6b]indole derivatives were synthesized and their chemical structures confirmed by 1H NMR and 13C NMR, elemental, IR and mass spectrophotometric analyses. The in vitro antimalarial activities of these compounds were evaluated against the chloroquine-sensitive (D10) and the chloroquine-resistant (RSA11) strains of Plasmodium falciparum. The 1,2,4-triazino[5,6b]indole derivatives (4, 6 and 8) with a trifluoromethyl group at position 6 exhibit increased in vitro activity when compared to the unsubstituted analogues, which are all devoid of activity. The presence of the trifluoromethyl group in the 5H-1,2,4-triazolo[1',5',2,3]-1,2,4-triazino[5,6b]indole ring system leads to compounds with diminished antimalarial activity when compared to the corresponding unsubstituted analogues. The compounds associate with ferriprotoporphyrin IX and interact with DNA to more or less the same extent." @default.
• W2089709024 created "2016-06-24" @default.
• W2089709024 creator A5008786325 @default.
• W2089709024 creator A5062442118 @default.
• W2089709024 creator A5082730361 @default.
• W2089709024 date "2005-04-01" @default.
• W2089709024 modified "2023-09-26" @default.
• W2089709024 title "1,2,4-Triazino-[5,6b]indole derivatives: effects of the trifluoromethyl group on in vitro antimalarial activity" @default.
• W2089709024 cites W180766444 @default.
• W2089709024 cites W1976906219 @default.
• W2089709024 cites W1998835931 @default.
• W2089709024 cites W1999766902 @default.
• W2089709024 cites W2001455540 @default.
• W2089709024 cites W2017850777 @default.
• W2089709024 cites W2020568201 @default.
• W2089709024 cites W2030266118 @default.
• W2089709024 cites W2042018041 @default.
• W2089709024 cites W2042625254 @default.
• W2089709024 cites W2045133086 @default.
• W2089709024 cites W2050653861 @default.
• W2089709024 cites W2057832900 @default.
• W2089709024 cites W2065514776 @default.
• W2089709024 cites W2066395419 @default.
• W2089709024 cites W2082691747 @default.
• W2089709024 cites W2090095994 @default.
• W2089709024 cites W2092715709 @default.
• W2089709024 cites W2114168178 @default.
• W2089709024 cites W2157746760 @default.
• W2089709024 cites W2169690281 @default.
• W2089709024 cites W2171050240 @default.
• W2089709024 cites W2296263363 @default.
• W2089709024 cites W2405733645 @default.
• W2089709024 cites W2407137981 @default.
• W2089709024 cites W4233787690 @default.
• W2089709024 cites W4243954003 @default.
• W2089709024 cites W4361989844 @default.
• W2089709024 cites W79387094 @default.
• W2089709024 cites W8681322 @default.
• W2089709024 doi "https://doi.org/10.1016/j.bmc.2005.02.017" @default.
• W2089709024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15781403" @default.
• W2089709024 hasPublicationYear "2005" @default.
• W2089709024 type Work @default.
• W2089709024 sameAs 2089709024 @default.
• W2089709024 citedByCount "61" @default.
• W2089709024 countsByYear W20897090242012 @default.
• W2089709024 countsByYear W20897090242013 @default.
• W2089709024 countsByYear W20897090242014 @default.
• W2089709024 countsByYear W20897090242015 @default.
• W2089709024 countsByYear W20897090242016 @default.
• W2089709024 countsByYear W20897090242018 @default.
• W2089709024 countsByYear W20897090242019 @default.
• W2089709024 countsByYear W20897090242020 @default.
• W2089709024 countsByYear W20897090242021 @default.
• W2089709024 countsByYear W20897090242022 @default.
• W2089709024 countsByYear W20897090242023 @default.
• W2089709024 crossrefType "journal-article" @default.
• W2089709024 hasAuthorship W2089709024A5008786325 @default.
• W2089709024 hasAuthorship W2089709024A5062442118 @default.
• W2089709024 hasAuthorship W2089709024A5082730361 @default.
• W2089709024 hasConcept C103319777 @default.
• W2089709024 hasConcept C163111631 @default.
• W2089709024 hasConcept C178790620 @default.
• W2089709024 hasConcept C185592680 @default.
• W2089709024 hasConcept C192527728 @default.
• W2089709024 hasConcept C202751555 @default.
• W2089709024 hasConcept C203014093 @default.
• W2089709024 hasConcept C2776442012 @default.
• W2089709024 hasConcept C2778048844 @default.
• W2089709024 hasConcept C2778371730 @default.
• W2089709024 hasConcept C2780263894 @default.
• W2089709024 hasConcept C2780378348 @default.
• W2089709024 hasConcept C55493867 @default.
• W2089709024 hasConcept C71240020 @default.
• W2089709024 hasConcept C86803240 @default.
• W2089709024 hasConceptScore W2089709024C103319777 @default.
• W2089709024 hasConceptScore W2089709024C163111631 @default.
• W2089709024 hasConceptScore W2089709024C178790620 @default.
• W2089709024 hasConceptScore W2089709024C185592680 @default.
• W2089709024 hasConceptScore W2089709024C192527728 @default.
• W2089709024 hasConceptScore W2089709024C202751555 @default.
• W2089709024 hasConceptScore W2089709024C203014093 @default.
• W2089709024 hasConceptScore W2089709024C2776442012 @default.
• W2089709024 hasConceptScore W2089709024C2778048844 @default.
• W2089709024 hasConceptScore W2089709024C2778371730 @default.
• W2089709024 hasConceptScore W2089709024C2780263894 @default.
• W2089709024 hasConceptScore W2089709024C2780378348 @default.
• W2089709024 hasConceptScore W2089709024C55493867 @default.
• W2089709024 hasConceptScore W2089709024C71240020 @default.
• W2089709024 hasConceptScore W2089709024C86803240 @default.
• W2089709024 hasIssue "8" @default.
• W2089709024 hasLocation W20897090241 @default.
• W2089709024 hasLocation W20897090242 @default.
• W2089709024 hasOpenAccess W2089709024 @default.
• W2089709024 hasPrimaryLocation W20897090241 @default.
• W2089709024 hasRelatedWork W1996351400 @default.
• W2089709024 hasRelatedWork W2033763597 @default.
• W2089709024 hasRelatedWork W2084432314 @default.
• W2089709024 hasRelatedWork W2089709024 @default.

• next