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- W2089714144 endingPage "79" @default.
- W2089714144 startingPage "65" @default.
- W2089714144 abstract "Introduction: The peroxisome proliferator-activated receptor (PPAR)-α and -γ agonists, fibrates and glitazones, are effective treatments for dyslipidemia and type 2 diabetes mellitus, respectively, but exhibit class-related, as well as compound-specific safety characteristics. Areas covered: This article reviews the profiles of PPAR-α, PPAR-γ, and dual PPAR-α/γ agonists with regard to class-related and compound-specific efficacy and adverse effects. We explore how learnings from first-generation drugs are being applied to develop safer PPAR-targeted therapies. Expert opinion: The finding that rosiglitazone may increase risk for cardiovascular events has led to regulatory guidelines requiring demonstration of cardiovascular safety in appropriate outcome trials for new type 2 diabetes mellitus drugs. The emerging data on the possibly increased risk of bladder cancer with pioglitazone may prompt the need for post-approval safety studies for new drugs. Since PPAR-α and -γ affect key cardiometabolic risk factors (diabetic dyslipidemia, insulin resistance, hyperglycemia, and inflammation) in a complementary fashion, combining their benefits has emerged as a particularly attractive option. New PPAR-targeted therapies that balance the relative potency and/or activity toward PPAR-α and -γ have shown promise in retaining efficacy while reducing potential side effects." @default.
- W2089714144 created "2016-06-24" @default.
- W2089714144 creator A5004083139 @default.
- W2089714144 creator A5013757620 @default.
- W2089714144 creator A5028793097 @default.
- W2089714144 creator A5070441005 @default.
- W2089714144 date "2012-11-08" @default.
- W2089714144 modified "2023-10-12" @default.
- W2089714144 title "Examining the safety of PPAR agonists – current trends and future prospects" @default.
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