Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089714628> ?p ?o ?g. }
- W2089714628 endingPage "52" @default.
- W2089714628 startingPage "45" @default.
- W2089714628 abstract "The second-order relay neurons in the nucleus tractus solitarius (NTS) receive numerous peripheral afferent inputs mainly from the vagus nerve. Their activity is modified by several neuromodulators and hence autonomic responses are properly regulated. Serotonin (5-HT) is an important candidate for such neuromodulators, since serotonergic inputs and distribution of 5-HT receptors are provided in the NTS. However, its mechanism of action remains unclear. To evaluate the serotonergic modulation of synaptic transmission, we examined the effects of 5-HT (1.0–10.0 μM) on the solitary tract-evoked excitatory postsynaptic currents (eEPSCs) and spontaneously occurring EPSCs (sEPSCs) in the preselected second-order neurons of the rat NTS. 5-HT concentration-dependently decreased the amplitude of eEPSCs, which was accompanied by an increase in paired-pulse ratio. The inhibitory effect of 5-HT was mimicked by α-methylserotonin and blocked by ketanserin. 5-HT had no effect on the inward current induced in the NTS neurons by topically applied α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). On the other hand, 5-HT increased the frequency of sEPCSs without effect on their amplitude. This excitatory effect of 5-HT was mimicked by 2-methylserotonin and antagonized by ondansetron. The results suggest a dual modulation of the excitatory synaptic transmission by 5-HT in the NTS; presynaptic inhibition of the peripheral inputs synapsing to the relay neurons via 5-HT2 receptors and presynaptic excitation of inputs from the intrinsic local network via 5-HT3 receptors. These effects of 5-HT may provide important means of optimizing the autonomic responses mediated by the NTS network." @default.
- W2089714628 created "2016-06-24" @default.
- W2089714628 creator A5036697515 @default.
- W2089714628 creator A5076970365 @default.
- W2089714628 creator A5078574132 @default.
- W2089714628 date "2011-12-01" @default.
- W2089714628 modified "2023-10-16" @default.
- W2089714628 title "Distinct modulatory effects of 5-HT on excitatory synaptic transmissions in the nucleus tractus solitarius of the rat" @default.
- W2089714628 cites W1528984165 @default.
- W2089714628 cites W1551693078 @default.
- W2089714628 cites W1555054303 @default.
- W2089714628 cites W1559166589 @default.
- W2089714628 cites W1581615324 @default.
- W2089714628 cites W1589107006 @default.
- W2089714628 cites W1803784983 @default.
- W2089714628 cites W1965070710 @default.
- W2089714628 cites W1969855549 @default.
- W2089714628 cites W1972995459 @default.
- W2089714628 cites W1973544773 @default.
- W2089714628 cites W1976017715 @default.
- W2089714628 cites W1984687181 @default.
- W2089714628 cites W1986472147 @default.
- W2089714628 cites W1988429055 @default.
- W2089714628 cites W1992536359 @default.
- W2089714628 cites W1993406913 @default.
- W2089714628 cites W1996269543 @default.
- W2089714628 cites W2001296308 @default.
- W2089714628 cites W2015011531 @default.
- W2089714628 cites W2015367475 @default.
- W2089714628 cites W2017061523 @default.
- W2089714628 cites W2020460680 @default.
- W2089714628 cites W2021897528 @default.
- W2089714628 cites W2023251878 @default.
- W2089714628 cites W2024416730 @default.
- W2089714628 cites W2042023583 @default.
- W2089714628 cites W2051696544 @default.
- W2089714628 cites W2058259805 @default.
- W2089714628 cites W2058521636 @default.
- W2089714628 cites W2059278538 @default.
- W2089714628 cites W2071190305 @default.
- W2089714628 cites W2077459558 @default.
- W2089714628 cites W2079169549 @default.
- W2089714628 cites W2084698802 @default.
- W2089714628 cites W2094391965 @default.
- W2089714628 cites W2094701888 @default.
- W2089714628 cites W2104671291 @default.
- W2089714628 cites W2117271843 @default.
- W2089714628 cites W2117961965 @default.
- W2089714628 cites W2126931614 @default.
- W2089714628 cites W2129488948 @default.
- W2089714628 cites W2131761257 @default.
- W2089714628 cites W2160938902 @default.
- W2089714628 cites W2161123433 @default.
- W2089714628 cites W2168767331 @default.
- W2089714628 cites W2169699020 @default.
- W2089714628 cites W2285774466 @default.
- W2089714628 cites W74452585 @default.
- W2089714628 doi "https://doi.org/10.1016/j.ejphar.2011.09.164" @default.
- W2089714628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21968141" @default.
- W2089714628 hasPublicationYear "2011" @default.
- W2089714628 type Work @default.
- W2089714628 sameAs 2089714628 @default.
- W2089714628 citedByCount "12" @default.
- W2089714628 countsByYear W20897146282012 @default.
- W2089714628 countsByYear W20897146282014 @default.
- W2089714628 countsByYear W20897146282015 @default.
- W2089714628 countsByYear W20897146282016 @default.
- W2089714628 countsByYear W20897146282017 @default.
- W2089714628 countsByYear W20897146282018 @default.
- W2089714628 countsByYear W20897146282019 @default.
- W2089714628 countsByYear W20897146282020 @default.
- W2089714628 countsByYear W20897146282022 @default.
- W2089714628 crossrefType "journal-article" @default.
- W2089714628 hasAuthorship W2089714628A5036697515 @default.
- W2089714628 hasAuthorship W2089714628A5076970365 @default.
- W2089714628 hasAuthorship W2089714628A5078574132 @default.
- W2089714628 hasConcept C112592302 @default.
- W2089714628 hasConcept C169760540 @default.
- W2089714628 hasConcept C170493617 @default.
- W2089714628 hasConcept C17077164 @default.
- W2089714628 hasConcept C185592680 @default.
- W2089714628 hasConcept C197341189 @default.
- W2089714628 hasConcept C200170125 @default.
- W2089714628 hasConcept C2775864247 @default.
- W2089714628 hasConcept C2779929655 @default.
- W2089714628 hasConcept C2780723820 @default.
- W2089714628 hasConcept C2910581834 @default.
- W2089714628 hasConcept C37000724 @default.
- W2089714628 hasConcept C53910766 @default.
- W2089714628 hasConcept C55493867 @default.
- W2089714628 hasConcept C86803240 @default.
- W2089714628 hasConceptScore W2089714628C112592302 @default.
- W2089714628 hasConceptScore W2089714628C169760540 @default.
- W2089714628 hasConceptScore W2089714628C170493617 @default.
- W2089714628 hasConceptScore W2089714628C17077164 @default.
- W2089714628 hasConceptScore W2089714628C185592680 @default.
- W2089714628 hasConceptScore W2089714628C197341189 @default.
- W2089714628 hasConceptScore W2089714628C200170125 @default.