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• W2089737734 abstract "Objective— To evaluate mRNA expression of several proinflammatory and anti‐inflammatory cytokines and chemokines in equine unstimulated and interleukin‐1β (IL‐1β)‐stimulated chondrocytes. Study Design— In vitro experiment using equine chondrocyte cultures. Sample Population— Whole articular cartilage from metacarpophalangeal joints (n=5 horses; 10 fetlocks). Methods— Chondrocyte monolayer cultures were established from digested adult equine articular cartilage and stimulated with 5 ng/mL of recombinant human IL‐1β. RNA was extracted from the cells 24 hours after stimulation. IL‐1β, IL‐4, IL‐6, IL‐8, tumor necrosis factor‐α (TNF‐α), and ubiquitin (house keeping gene) mRNA expression were investigated by real‐time RT‐PCR. Results— IL‐1β, IL‐6, and IL‐8 mRNA were expressed in unstimulated chondrocytes from macroscopically normal joints and were significantly up‐regulated after stimulation (5/5 horses). IL‐4 mRNA was not detected in any samples (0/5 horses). TNF‐α mRNA, by comparison, was expressed in 2/5 unstimulated samples and in all stimulated samples but a considerable sample variation in response to IL‐1β stimulation was observed. Conclusions— Equine chondrocytes express mRNA for several proinflammatory cytokines and chemokines and IL‐1β modulates their expression. Clinical Relevance— Chondrocytes express proinflammatory cytokines and chemokines capable of modulating a local inflammatory cascade in articular cartilage, which could potentially lead to focal degradation and osteoarthritis." @default.
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• W2089737734 date "2007-04-01" @default.
• W2089737734 modified "2023-10-14" @default.
• W2089737734 title "Cytokine and Chemokine Gene Expression of IL-1? Stimulated Equine Articular Chondrocytes" @default.
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• W2089737734 doi "https://doi.org/10.1111/j.1532-950x.2007.00253.x" @default.
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