FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089739590> ?p ?o ?g. }

• W2089739590 endingPage "19135" @default.
• W2089739590 startingPage "19122" @default.
• W2089739590 abstract "Podocyte injury resulting from a loss of differentiation is the hallmark of many glomerular diseases. We previously showed that retinoic acid (RA) induces podocyte differentiation via stimulation of the cAMP pathway. However, many podocyte maturity markers lack binding sites for RA-response element or cAMP-response element (CREB) in their promoter regions. We hypothesized that transcription factors induced by RA and downstream of CREB mediate podocyte differentiation. We performed microarray gene expression studies in human podocytes treated with and without RA to identify differentially regulated genes. In comparison with known CREB target genes, we identified Krüppel-like factor 15 (KLF15), a kidney-enriched nuclear transcription factor, that has been previously shown to mediate cell differentiation. We confirmed that RA increased KLF15 expression in both murine and human podocytes. Overexpression of KLF15 stimulated expression of differentiation markers in both wild-type and HIV-1-infected podocytes. Also, KLF15 binding to the promoter regions of nephrin and podocin was increased in RA-treated podocytes. Although KLF15(-/-) mice at base line had minimal phenotype, lipopolysaccharide- or adriamycin-treated KLF15(-/-) mice had a significant increase in proteinuria and podocyte foot process effacement with a reduction in the expression of podocyte differentiation markers as compared with the wild-type treated mice. Finally, KLF15 expression was reduced in glomeruli isolated from HIV transgenic mice as well as in kidney biopsies from patients with HIV-associated nephropathy and idiopathic focal segmental glomerulosclerosis. These results indicate a critical role of KLF15 in mediating podocyte differentiation and in protecting podocytes against injury." @default.
• W2089739590 created "2016-06-24" @default.
• W2089739590 creator A5004877715 @default.
• W2089739590 creator A5021913849 @default.
• W2089739590 creator A5025947755 @default.
• W2089739590 creator A5032323063 @default.
• W2089739590 creator A5032951414 @default.
• W2089739590 creator A5033563716 @default.
• W2089739590 creator A5048718607 @default.
• W2089739590 creator A5049482556 @default.
• W2089739590 creator A5052863332 @default.
• W2089739590 creator A5055025477 @default.
• W2089739590 creator A5066125347 @default.
• W2089739590 creator A5076138766 @default.
• W2089739590 date "2012-06-01" @default.
• W2089739590 modified "2023-10-16" @default.
• W2089739590 title "Krüppel-like Factor 15 (KLF15) Is a Key Regulator of Podocyte Differentiation" @default.
• W2089739590 cites W1549139000 @default.
• W2089739590 cites W1963937649 @default.
• W2089739590 cites W1964761209 @default.
• W2089739590 cites W1967525844 @default.
• W2089739590 cites W1971498397 @default.
• W2089739590 cites W1986416472 @default.
• W2089739590 cites W1994144521 @default.
• W2089739590 cites W1998958410 @default.
• W2089739590 cites W2008864584 @default.
• W2089739590 cites W2017695960 @default.
• W2089739590 cites W2018509996 @default.
• W2089739590 cites W2019591105 @default.
• W2089739590 cites W2019676554 @default.
• W2089739590 cites W2019783107 @default.
• W2089739590 cites W2021278812 @default.
• W2089739590 cites W2022532021 @default.
• W2089739590 cites W2041222430 @default.
• W2089739590 cites W2052352814 @default.
• W2089739590 cites W2055351499 @default.
• W2089739590 cites W2058374133 @default.
• W2089739590 cites W2066126648 @default.
• W2089739590 cites W2074324848 @default.
• W2089739590 cites W2107661284 @default.
• W2089739590 cites W2107782059 @default.
• W2089739590 cites W2107793453 @default.
• W2089739590 cites W2112549609 @default.
• W2089739590 cites W2117044603 @default.
• W2089739590 cites W2118747134 @default.
• W2089739590 cites W2121809763 @default.
• W2089739590 cites W2122085314 @default.
• W2089739590 cites W2124000892 @default.
• W2089739590 cites W2135236140 @default.
• W2089739590 cites W2137571953 @default.
• W2089739590 cites W2155821873 @default.
• W2089739590 cites W2162735075 @default.
• W2089739590 cites W2164334076 @default.
• W2089739590 cites W2171001136 @default.
• W2089739590 cites W2171936044 @default.
• W2089739590 cites W4249614921 @default.
• W2089739590 doi "https://doi.org/10.1074/jbc.m112.345983" @default.
• W2089739590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3365945" @default.
• W2089739590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22493483" @default.
• W2089739590 hasPublicationYear "2012" @default.
• W2089739590 type Work @default.
• W2089739590 sameAs 2089739590 @default.
• W2089739590 citedByCount "86" @default.
• W2089739590 countsByYear W20897395902012 @default.
• W2089739590 countsByYear W20897395902013 @default.
• W2089739590 countsByYear W20897395902014 @default.
• W2089739590 countsByYear W20897395902015 @default.
• W2089739590 countsByYear W20897395902016 @default.
• W2089739590 countsByYear W20897395902017 @default.
• W2089739590 countsByYear W20897395902018 @default.
• W2089739590 countsByYear W20897395902019 @default.
• W2089739590 countsByYear W20897395902020 @default.
• W2089739590 countsByYear W20897395902021 @default.
• W2089739590 countsByYear W20897395902022 @default.
• W2089739590 countsByYear W20897395902023 @default.
• W2089739590 crossrefType "journal-article" @default.
• W2089739590 hasAuthorship W2089739590A5004877715 @default.
• W2089739590 hasAuthorship W2089739590A5021913849 @default.
• W2089739590 hasAuthorship W2089739590A5025947755 @default.
• W2089739590 hasAuthorship W2089739590A5032323063 @default.
• W2089739590 hasAuthorship W2089739590A5032951414 @default.
• W2089739590 hasAuthorship W2089739590A5033563716 @default.
• W2089739590 hasAuthorship W2089739590A5048718607 @default.
• W2089739590 hasAuthorship W2089739590A5049482556 @default.
• W2089739590 hasAuthorship W2089739590A5052863332 @default.
• W2089739590 hasAuthorship W2089739590A5055025477 @default.
• W2089739590 hasAuthorship W2089739590A5066125347 @default.
• W2089739590 hasAuthorship W2089739590A5076138766 @default.
• W2089739590 hasBestOaLocation W20897395901 @default.
• W2089739590 hasConcept C104317684 @default.
• W2089739590 hasConcept C134018914 @default.
• W2089739590 hasConcept C148738053 @default.
• W2089739590 hasConcept C1629964 @default.
• W2089739590 hasConcept C2776855237 @default.
• W2089739590 hasConcept C2777146197 @default.
• W2089739590 hasConcept C2779561371 @default.
• W2089739590 hasConcept C2780091579 @default.
• W2089739590 hasConcept C2780819817 @default.

• next