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• W2089772548 abstract "Background: In fMRI examinations, it is very important to select appropriate paradigms assessing the brain function of interest. In addition, the patients’ ability to perform the required cognitive tasks during fMRI must be taken into account. Purpose: To evaluate two language paradigms, word generation and sentence reading for their usefulness in examinations of aphasic patients and to make suggestions for improvements of clinical fMRI. Material and Methods: Five patients with aphasia after stroke or trauma sequelae were examined by fMRI. The patients’ language ability was screened by neurolinguistic tests and elementary pre-fMRI language tests. Results: The sentence-reading paradigm succeeded to elicit adequate language-related activation in perilesional areas whereas the word generation paradigm failed. These findings were consistent with results on the behavioral tests in that all patients showed very poor performance in phonemic fluency, but scored well above mean at a reading comprehension task. Conclusion: The sentence-reading paradigm is appropriate to assess language function in this patient group, while the word-generation paradigm seems to be inadequate. In addition, it is crucial to use elementary pre-fMRI language tests to guide the fMRI paradigm decision." @default.
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• W2089772548 date "2010-07-01" @default.
• W2089772548 modified "2023-10-18" @default.
• W2089772548 title "Clinical fMRI of language function in aphasic patients: Reading paradigm successful, while word generation paradigm fails" @default.
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• W2089772548 doi "https://doi.org/10.3109/02841851003753456" @default.
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